Osteocalcin Antibody | EMD Millipore AB10911 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Osteocalcin Antibody

catalog :

AB10911

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:200; loading ...; fig 5a	Zhang Y, Yin J, Ding H, Zhang W, Zhang C, Gao Y. Protective effect of VK2 on glucocorticoid-treated MC3T3-E1 cells. Int J Mol Med. 2017;39:160-166 pubmed publisher
	Tam E, McGrath M, Sladkova M, AlManaie A, Alostaad A, de Peppo G. Hypothermic and cryogenic preservation of tissue-engineered human bone. Ann N Y Acad Sci. 2020;1460:77-87 pubmed publisher
	Chen J, Lazarenko O, Zhao H, Alund A, Shankar K. Maternal obesity impairs skeletal development in adult offspring. J Endocrinol. 2018;239:33–47 pubmed publisher
	Sladkova M, Alawadhi R, Jaragh Alhaddad R, Esmael A, Alansari S, Saad M, et al. Segmental Additive Tissue Engineering. Sci Rep. 2018;8:10895 pubmed publisher
	Engel N, Adamus A, Schauer N, Kuhn J, Nebe B, Seitz G, et al. Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. PLoS ONE. 2017;12:e0169742 pubmed publisher
	Lim K, Hexiu J, Kim J, Seonwoo H, Choung P, Chung J. Synergistic effects of orbital shear stress on in vitro growth and osteogenic differentiation of human alveolar bone-derived mesenchymal stem cells. Biomed Res Int. 2014;2014:316803 pubmed publisher

product information

Catalog Number :

AB10911

Subcategory :

Cell Structure

Product Name :

Anti-Osteocalcin Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P02818

Host Name :

Rabbit

Antigen :

Osteocalcin

Conjugate :

Serum

Product Description :

Anti-Osteocalcin Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

Osteocalcin belongs to the osteocalcin/matrix Gla protein family. It constitutes 1 to 2% of the total bone protein. It is made by osteoblasts, and is a major component of the noncollagenous bone matrix. It has a high affinity for calcium and binds strongly to apatite. Sixty to ninety percent of de novo synthesized osteocalcin is incorporated into the bone matrix where it binds to hydroxyapatite during matrix mineralization. The remainder of the osteocalcin is released into the circulation where it can be measured as a sensitive marker of bone formation. Osteocalcin found in serum is almost exclusively derived from the bone formation with little or no contribution from the resorption process. Drugs acting primarily on bone resorption, such as bisphosphonates, induce a rapid decline in specific bone resorption markers, whereas osteocalcin levels only change after extended therapy periods, in accordance with the expected dynamics of a bone formation marker. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.

ALT Names :

Bone Gla protein ;Gamma-carboxyglutamic acid-containing protein ;bone gamma-carboxyglutamate (gla) protein (osteocalcin)

Immunogen :

Synthetic peptide corresponding to aa 59-74 of osteocalcin protein.

Specificity :

The antibody reacts with the osteocalcin protein.

Package Size :

100 μL

Uses :

Western Blotting;Immunohistochemistry

Storage :

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.