Osteopontin Antibody | EMD Millipore AB10910 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Osteopontin Antibody

catalog :

AB10910

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry knockout validation

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; mouse; 1:50; loading ...; fig 2a immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 2a	Gawlik K, Holmberg J, Svensson M, Einerborg M, Oliveira B, Deierborg T, et al. Potent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy. Sci Rep. 2017;7:44059 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 3d	Leon S, Fernandois D, Sull A, Sull J, Calder M, Hayashi K, et al. Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function. Sci Rep. 2016;6:29073 pubmed publisher

product information

Catalog Number :

AB10910

Subcategory :

Cell Structure

Product Name :

Anti-Osteopontin Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P10451

Host Name :

Rabbit

Antigen :

Osteopontin

Conjugate :

Serum

Product Description :

Anti-Osteopontin Antibody

Cross Reactivity :

Human;Mouse

Background :

Osteopontin is a single-chain polypeptide. It is highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell attachment/signaling. Expression of osteopontin in a variety of tissues indicates a multiplicity of functions that involve one or more of these conserved motifs. While the lack of a clear phenotype in osteopontin "knockout" mice has not established a definitive role for osteopontin in any tissue, recent studies have provided some novel and intriguing insights into the versatility of this enigmatic protein in diverse biological events, including developmental processes, wound healing, immunological responses, tumorigenesis, bone resorption, and calcification. The ability of osteopontin to stimulate cell activity through multiple receptors linked to several interactive signaling pathways can account for much of the functional diversity.

ALT Names :

Bone sialoprotein 1 ;SPP1/CALPHA1 fusion ;Urinary stone protein;bone sialoprotein I ;osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein ;secreted phosphoprotein 1 ;secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) ;secreted phosphoprotein-1 (osteopontin, bone sialoprotein)

Immunogen :

Synthetic peptide corresponding to aa 75-90 of osteopontin protein.

Specificity :

The antibody reacts with the 60 kDa osteopontin protein.

Package Size :

100 μL

Uses :

Western Blotting;Immunohistochemistry

Storage :

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.