mGluR8 Antibody | EMD Millipore AB10556 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

mGluR8 Antibody

catalog :

AB10556

quantity :

100 µL

clonality :

polyclonal

host :

guinea pigs

conjugate :

nonconjugated

reactivity :

dog, cow, chimpanzee

application :

immunohistochemistry

product information

Catalog Number :

AB10556

Subcategory :

Neuroscience

Product Name :

Anti-mGluR8 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

O00222

Host Name :

Guinea Pig

Antigen :

mGluR8

Conjugate :

Serum

Product Description :

Anti-mGluR8 Antibody

Cross Reactivity :

Rat

Background :

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

ALT Names :

glutamate metabotropic receptor 8;glutamate receptor;metabotropic 8

Immunogen :

This antibody is generated from guinea pigs immunized with a KLH-conjugated linear peptide selected from residues corresponding to the cytoplasmic domain of rat mGluR8.

Specificity :

This antibody recognizes mGluR8.

Package Size :

100 µL

Uses :

Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.