EBF-1 Antibody | EMD Millipore AB10523 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

EBF-1 Antibody

catalog :

AB10523

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, ChIP-Seq

citations: 3

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; fig 4c	Lu F, Wiedmer A, Martin K, Wickramasinghe P, Kossenkov A, Lieberman P. Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus. J Virol. 2017;91: pubmed publisher
ChIP-Seq; human; fig 3 western blot; human; fig 5h	Lu F, Chen H, Kossenkov A, DeWispeleare K, Won K, Lieberman P. EBNA2 Drives Formation of New Chromosome Binding Sites and Target Genes for B-Cell Master Regulatory Transcription Factors RBP-jκ and EBF1. PLoS Pathog. 2016;12:e1005339 pubmed publisher
	Szymula A, Palermo R, Bayoumy A, Groves I, Ba Abdullah M, Holder B, et al. Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome. PLoS Pathog. 2018;14:e1006890 pubmed publisher

product information

Catalog Number :

AB10523

Subcategory :

Neuroscience

Product Name :

Anti-EBF-1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q07802

Host Name :

Rabbit

Antigen :

EBF-1

Conjugate :

Affinity Purified

Product Description :

Anti-EBF-1 Antibody

Cross Reactivity :

Human;Mouse

Background :

The family of Early B-cell Factor (EBF) or Collier/Olf-1/EBF (COE) proteins, EBF1, EBF2, and EBF3, are ubiquitous zinc-binding transcription factors found in many species, including human, Drosophila melanogaster, and Caenorhabditis elegans. EBF1 is abundantly expressed in early B-cells, lymph node, spleen, and adipose tissue. Low levels of EBF1 have also been detected in the brain, heart, skeletal muscle, and kidney. EBF proteins are capable of forming homo- and heterodimers that bind to DNA at specific sites that include the sequence 5'-ATTCCCNNGGGAATT-3'. EBF1, the prototypical member of this family, may employ epigenetic mechanisms, such as DNA methylation and chromatin remodeling, to regulate genes involved in B-cell development such as Pax5. The second member of this family EBF2 is involved in bone development, adipogenesis, and CNS development, processes which may also hinge on EBF1. EBF3 has been characterized as a tumor suppressor protein, due to its role in regulating multiple genes such as those for cyclins and CDKs which control cell growth, differentiation, and apoptosis. However, emerging evidence indicates that all EBF proteins may play a role in the development of various cancers.

ALT Names :

Transcription factor COE1;O/E-1;OE-1;Early B-cell factor

Immunogen :

KLH-conjugated linear peptide corresponding to mouse EBF-1.

Specificity :

This antibody recognizes EBF-1 but not EBF-2 or EBF-3.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin);Immunofluorescence;Dot Blot

Storage :

Stable for 1 year at 2-8°C from date of receipt