DARPP-32 Antibody | EMD Millipore AB10518 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

DARPP-32 Antibody

catalog :

AB10518

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, dogs

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:1000; loading ...; fig 2g	Wu Z, Parry M, Hou X, Liu M, Wang H, Cain R, et al. Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease. Nat Commun. 2020;11:1105 pubmed publisher
	Enterría Morales D, López López I, Lopez Barneo J, d Anglemont de Tassigny X. Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan-Neuronal Activation in the Female Mouse. PLoS ONE. 2016;11:e0164391 pubmed publisher
	Wright J, Ermine C, Jørgensen J, Parish C, Thompson L. Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury. Front Cell Neurosci. 2016;10:177 pubmed publisher

product information

Catalog Number :

AB10518

Subcategory :

Neuroscience

Product Name :

Anti-DARPP-32 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q60829

Host Name :

Rabbit

Antigen :

DARPP-32

Conjugate :

Affinity Purified

Product Description :

Anti-DARPP-32 Antibody

Cross Reactivity :

Rat;Mouse;Rhesus Macaque;Canine

Background :

Dopamine- and cAMP-regulated neuronal phosphoprotein (DARP-32) is a cytoplasmic member of the protein phosphatase inhibitor 1 family. DARP-32 is a multifunctional protein kinase and protein phosphatase regulator, depending on the site of its activation. It possesses at least four sites that can be phosphorylated. Phosphorylation by PKA at Thr34 stimulates DARP-32 to act as a protein-phosphatase-1 (PP-1) inhibitor. However, phosphorylation at Thr75 will inhibit Thr34 phosphorylation. This selective, bidirectional regulation allows DARPP-32 to have a wide range of influence on downstream physiological effectors such as: ion pumps, neurotransmitter receptors, voltage-gate ion channels, and transcriptional factors. Studies suggest that it may also have a role in the Circadian System photic pathway. Overexpression of DARPP-32 has been linked with antiapoptotic mechanisms of cancer cells and has been observed in breast, colon, esophagus, gastric, and prostate cancer tissues.

ALT Names :

protein phosphatase 1, regulatory (inhibitor) subunit 1B;dopamine and cAMP-regulated neuronal phosphoprotein 32;dopamine and cAMP regulated phosphoprotein;protein phosphatase 1 regulatory subunit 1B;Dopamine- and cAMP-regulated neuronal phosphoprotein;protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)

Immunogen :

KLH-conjugated linear peptide corresponding to mouse DARPP-32 near the N-terminus.

Specificity :

This antibody recognizes DARPP-32 near the N-terminus.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt