PHB2 Antibody | EMD Millipore AB10198 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PHB2 Antibody

catalog :

AB10198

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs, bovine

application :

western blot

product information

Catalog Number :

AB10198

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-PHB2 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q99623

Host Name :

Rabbit

Antigen :

PHB2

Conjugate :

Affinity Purified

Product Description :

Anti-PHB2 Antibody

Cross Reactivity :

Human;Mouse

Background :

The prohibitin family of mitochondrial proteins regulate replicative lifespan. In the mitochondria, Prohibin 2 (PHB2) is thought to be involved in mitochondrial respiration activity and in aging. PHB2 translocates to the nucleus in an estrogen receptor (ER)--dependent manner, where it protects sister-chromatid cohesion in mitosis. PHB2 functions as an ER-selective coregulator that represses the activity of estrogens. PHB2 is essential for proper mitotic progression since it protects the centromeric cohesion from phosphorylation by Plk1 during early mitosis. PHB2 also reepresses transcription by recruiting histone deacetylases.

ALT Names :

B-cell associated protein;B-cell receptor-associated protein BAP37;Repressor of estrogen receptor activity ;Prohibitin 2

Immunogen :

Synthetic peptide corresponding to a.a. 81-95 of human PHB2, conjugated to KLH.

Specificity :

This antibody recognizes PHB2.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.