NR1D1 (Rev-ErbA α) Antibody | EMD Millipore AB10130 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NR1D1 (Rev-ErbA α) Antibody

catalog :

AB10130

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

AB10130

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-NR1D1 (Rev-ErbA α) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P20393

Host Name :

Rabbit

Antigen :

NR1D1 (Rev-ErbA α)

Conjugate :

Affinity Purified

Product Description :

Anti-NR1D1 (Rev-ErbA α) Antibody

Cross Reactivity :

Human

Background :

Rev-ErbA alpha (NR1D1 or nuclear receptor subfamily 1, group D, member 1), is a member of the Rev-ErbA family of nuclear receptors and is a transcriptional repressor. In mammals, Rev-Erbα is highly expressed in the liver, skeletal muscle, adipose tissue, and the brain, participating in the development and circadian regulation of these tissues. Rev-Erbα regulates gene transcription by directly binding to target response elements (RevREs), comprises an A/T-rich flank followed by AGGTCA. Rev-Erbα mediates repression by recruiting the corepressor N-CoR, which then activates the histone deacetylase (HDAC) 3. A number of target genes has been identified for Rev-Erbα, including the lipoproteins ApoA1 and ApoCIII, hydratase dehydrogenase, the circadian factor BMAL, and the anti-fibrinolytic factor PAI-1. Many of these genes are coordinately regulated by Rev-erbα and the RAR-related orphan receptor RORα, which share the same response elements but exert opposite effects on gene transcription. Crosstalk between Rev-Erbα and RORα likely acts to fine-tune of their target physiologic networks, such as circadian rhythms, metabolic homeostasis, and inflammation.

ALT Names :

V-erbA-related protein EAR-1;nuclear receptor subfamily 1, group D, member 1;thyroid hormone receptor, alpha-like

Immunogen :

KLH-conjugated linear peptide corresponding to residues surrounding the area near the N-terminus region of NR1D1.

Specificity :

This antibody recognizes NR1D1 near the N-terminus.

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Maintain refrigerated at 2-8°C for 1 year from date of receipt.