phospho-ITCH (pT222) Antibody | EMD Millipore AB10050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-ITCH (pT222) Antibody

catalog :

AB10050

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot

product information

Catalog Number :

AB10050

Subcategory :

Protein Trafficking

Product Name :

Anti-phospho-ITCH (pT222) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q96J02

Host Name :

Rabbit

Antigen :

phospho-ITCH (pT222)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-ITCH (pT222) Antibody

Cross Reactivity :

Human

Background :

ITCH is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. ITCH regulates the transcriptional activity of several transcription factors including the hematopoietic transcription factor NF-E2, and may play an important role in the regulation of immune response. ITCH down-regulates Epstein-Barr virus LMP2A activity in B cell signaling, and also interacts with NOTCH1, OCLN, JUN, and JUNB. ITCH has a wide tissue distribution and is localized within the nucleus and cytoplasm. Two ITCH splice variants have been described; an approximately 103 kDa form as well as a truncated form (~98 kDa) lacking 42 amino acids in the N-terminal half of the protein. ITCH contains a MAP Kinase binding site and its activity is modulated by phosphorylation at multiple threonine residues by JNK1.

ALT Names :

Itchy homolog E3 ubiquitin protein ligase; AIP4; NAPP1

Immunogen :

Synthetic peptide corresponding to a portion of human ITCH encompassing the phosphorylated Threonine at position 222 (PPPpTPRRP).

Specificity :

Human ITCH phosphorylated on threonine 222 (T222).

Package Size :

100 µg

Uses :

Dot Blot;Western Blotting

Storage :

Maintain at 2-8°C for up to 12 months from date of receipt