Ubiquityl Histone H2A.X (Lys119) Antibody | EMD Millipore AB10029 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Ubiquityl Histone H2A.X (Lys119) Antibody

catalog :

AB10029

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

AB10029

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Ubiquityl Histone H2A.X (Lys119) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P16104

Host Name :

Rabbit

Antigen :

Ubiquityl Histone H2A.X (Lys119)

Conjugate :

Serum

Product Description :

Anti-Ubiquityl Histone H2A.X (Lys119) Antibody

Cross Reactivity :

Human;Mouse

Background :

H2AX is involved in DNA repair and the maintenance of genomic stability. It is been implicated both in homologous recombination and nonhomologous end joining DNA repair pathways. H2AX is thought to have a critical function in the recruitment of DNA repair factors and DNA damage-signaling proteins. H2A.X is ubiquitinated by RING1 and RNF2/RING2 complex providing a specific mark for transcriptional repression. In addition this protein can be ubiquitinated by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168 as result of double-stranded DNA breaks to recruit repair proteins a damaged site. H2AX is phosphorylated soon after the appearance of double-stranded breaks. Hyperphoshorylation of H2AX may be linked to chromatin fragmentation prior to apoptosis.

ALT Names :

H2AXK119Ub;Histone H2A.X Ubiquityl K119);H2A histone family, member X;H2AX histone

Immunogen :

Linear peptide containing ubiquitylated Lys119 of human Histone H2A.X.

Specificity :

This antibody recognizes Histone H2A.X when ubiquitylated at Lys119.

Package Size :

100 µL

Uses :

Western Blotting;Immunoprecipitation;Immunocytochemistry

Storage :

Stable for 1 year at -20°C from date of receipt.