CHIP/STUB1 Antibody | EMD Millipore AB10000 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CHIP/STUB1 Antibody

catalog :

AB10000

quantity :

100 µg

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

citations: 1

Reference
Kanack A, Newsom O, SCAGLIONE K. Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP. J Biol Chem. 2018;293:2735-2743 pubmed publisher

product information

Catalog Number :

AB10000

Subcategory :

Protein Trafficking

Product Name :

Anti-CHIP/STUB1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q9UNE7

Host Name :

Goat

Antigen :

CHIP/STUB1

Conjugate :

Affinity Purified

Product Description :

Anti-CHIP/STUB1 Antibody

Cross Reactivity :

Human;Chimpanzee

Background :

U box domain E3 ubiquitin ligase. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association. Also, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins.

ALT Names :

CHIP, STUB1

Immunogen :

Peptide with sequence DAFISENGWVEDY, from the C-terminus of the protein sequence according to NP_005852.

Package Size :

100 µg

Uses :

ELISA;Western Blotting

Storage :

Store at -20°C.