Tie2 Mouse mAb (Ab33) | EMD Millipore 610205-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tie2 Mouse mAb (Ab33)

catalog :

610205-50UG

quantity :

50 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

product information

Catalog Number :

610205-50UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-Tie2 Mouse mAb (Ab33)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

7010 (Hu), 21687 (Ms), 89804 (Rt)

Host Name :

Clone :

Ab33

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Tie2 Mouse mAb (Ab33)

Cross Reactivity :

Human, Mouse, Porcine, Rat

Background :

Angiopoietin-1 and its naturally occurring inhibitor, angiopoietin-2, exert their effects by inducing autophosphorylation of their signaling receptor Tie2. Phosphorylation of the receptor occurs during vasculogenesis and is required for its activity in regulating endothelial cell proliferation, differentiation and guiding the proper patterning of endothelial cells during blood vessel formation. Tie-2 is a transmembrane receptor-tyrosine kinase that is expressed by endothelial cells and primitive hematopoietic tissues. Tie2/Tek has been shown to be critical for endothelial cell survival, which is evidenced in part by the constitutive phosphorylation that is observed in quiescent endothelium. More recently a multifunction docking site has been identified on the receptor (Tyr1100) that serves as a binding site for other partners including Grb2, Grb7, and p85 and acting via an SH2 domain interaction.

ALT Names :

AA517024, CD202B, Hyk, MGC139569, TIE-2, VMCM, VMCM1, TEK tyrosine kinase, endothelial

Immunogen :

a recombinant protein consisting of amino acids 1-745 of human Tie2 fused to a His•Tag ® sequence

Specificity :

Recognizes the ~140-145 kDa Tie2 protein.

Package Size :

50 ug

Uses :

IH, WB, IP

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.