Telomerase (Ab-1) Rabbit pAb | EMD Millipore 582000-100UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Telomerase (Ab-1) Rabbit pAb

catalog :

582000-100UL

quantity :

100 uL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation, chromatin immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; loading ...; fig 5b	Endorf E, Qing H, Aono J, Terami N, Doyon G, Hyzny E, et al. Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes. Arterioscler Thromb Vasc Biol. 2017;37:301-311 pubmed publisher

product information

Catalog Number :

582000-100UL

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Telomerase (Ab-1) Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

7015 (Hu), 21752 (Ms), 301965 (Rt)

Host Name :

Conjugate :

Undiluted Serum

Isotype :

IgG

Product Description :

Anti-Telomerase (Ab-1) Rabbit pAb

Cross Reactivity :

Human, Mouse

Background :

The 3' ends of chromosomes are capped with telomere sequences (TTAGGG; 6-26 nucleotides in length) by ribonucleo-protein telomerase during DNA replication. Telomerase is an unusual RNA-dependent DNA polymerase that uses an RNA component to specify the addition of telomere. In ciliated protozoa and yeast, telomere length is maintained by regulating the activity of telomerase. Many mammalian cells do not express telomerase, resulting into shortening of the telomere with each cell division, ultimately causing chromosomal instability, aging and cell death. ~4.8 kb of telomeric DNA is lost with each cell division. Most recently, introduction of telomerase into normal human cells has been shown to extend normal cell life by ~20 doublings.

ALT Names :

EST2, hEST2, HTERT, MGC150124, TCS1, TELOMERASE, Telomerase Catalytic Subunit, TP2, TR, TRT, telomerase reverse transcriptase

Immunogen :

a synthetic peptide corresponding to amino acids from an internal region of the catalytic subunit of human telomerase reverse transcriptase (hTERT)

Specificity :

Recognizes the ~125 kDa telomerase (TERT) protein.

Package Size :

100 uL

Uses :

WB, IP, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.