Tau Mouse mAb (TAU-5) | EMD Millipore 577801-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tau Mouse mAb (TAU-5)

catalog :

577801-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat, domestic rabbit

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - free floating section, immunohistochemistry knockout validation

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; human; fig 2 immunohistochemistry - free floating section; human; fig 2 western blot; human; fig 1	FernÃ¡ndez Nogales M, Santos Galindo M, MerchÃ¡n Rubira J, Hoozemans J, RÃ¡bano A, Ferrer I, et al. Tau-positive nuclear indentations in P301S tauopathy mice. Brain Pathol. 2017;27:314-322 pubmed publisher
western blot; human; loading ...; fig 2c	Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3a western blot; human; 1:1000; loading ...; fig 8	Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher
western blot; mouse; 1:500; fig 1	Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, et al. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016;15:914-23 pubmed publisher
western blot; domestic rabbit; 1:1000; fig 3	Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed publisher
western blot; rat; 1:1000; fig 5e	Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, et al. Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc Natl Acad Sci U S A. 2015;112:E4465-74 pubmed publisher

product information

Catalog Number :

577801-100UG

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-Tau Mouse mAb (TAU-5)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

4137 (Hu), 17762 (Ms), 29477 (Rt)

Host Name :

Clone :

TAU-5

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Tau Mouse mAb (TAU-5)

Cross Reactivity :

Human, Mouse, Rat, Sheep

Background :

Tau is a neuronal microtubule-associated protein found predominantly in axons. Tau promotes tubulin polymerization and stabilizes microtubules, and it links certain signaling pathways to the cytoskeleton. Hyperphosphorylated tau is the major component of paired helical filaments, the building block of neurofibrillary lesions in Alzheimer’s disease. Hyperphosphorylation impairs the microtubule-binding function of tau, resulting in the destabilization of microtubules, and ultimately leading to degeneration of the affected neurons.

ALT Names :

DDPAC, FLJ31424, FTDP-17, MAPTL, MSTD, Mtapt, MTBT1, MTBT2, PHF TAU, PPND, pTau, RNPTAU, TAU, Tau 3r, Tau-1, TAU-FACTOR, Tau40, TAU4R, microtubule-associated protein tau

Immunogen :

purified bovine microtubule-associated proteins

Specificity :

Recognizes the ~45-68 kDa phosphorylated and unphosphorylated forms of tau.

Package Size :

100 ug

Uses :

IH, WB, IP, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-70°C). Do not store diluted antibody without carrier protein if the concentration is 50 ug/ml. Avoid repeated freeze-thaw.