P-Glycoprotein Mouse mAb (C219) | EMD Millipore 517310-500UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

P-Glycoprotein Mouse mAb (C219)

catalog :

517310-500UL

quantity :

500 uL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:50; loading ...; fig 2a	Sharanek A, Burban A, Burbank M, Le Guevel R, Li R, Guillouzo A, et al. Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs. Sci Rep. 2016;6:24709 pubmed publisher

product information

Catalog Number :

517310-500UL

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-P-Glycoprotein Mouse mAb (C219)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

5243 (Hu), 18671 (Ms), 170913 (Rt)

Host Name :

Clone :

C219

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-P-Glycoprotein Mouse mAb (C219)

Cross Reactivity :

Hamster, Human, Mouse, Rat

Background :

P-glycoprotein is typically expressed in cells with secretory and excretory functions. Its highest expression is in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P-glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P-glycoprotein have also been reported in multidrug-resistant cell lines and in various tumors, sarcomas and lymphomas.

ALT Names :

ABC20, Abcb1a, Abcb4, CD243, CLCS, EVI32, GP170, MDR, mdr-3, MDR1, Mdr1a, MDR1B, MGC163296, P-GLYCOPROTEIN, P-GP, Pgy-3, PGY1, ATP-binding cassette, sub-family B (MDR/TAP), member 1

Immunogen :

SDS-solubilized plasma membranes of a multidrug resistant (MDR) Chinese hamster ovary (CHO) cell line and a multidrug resistant human cell line

Specificity :

Recognizes the ~170 kDa MDR1 and MDR3 isoforms of P-glycoprotein.

Package Size :

500 uL

Uses :

FC, IH, WB, IC, IP, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.