PGC-1, C-Terminal (777-797) Rabbit pAb | EMD Millipore 516557-100UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PGC-1, C-Terminal (777-797) Rabbit pAb

catalog :

516557-100UL

quantity :

100 uL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 5j	Ruegsegger G, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, et al. Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J. 2019;33:4458-4472 pubmed publisher
western blot; mouse; loading ...; fig 2b	Koh J, Hancock C, Terada S, Higashida K, Holloszy J, Han D. PPARÎ² Is Essential for Maintaining Normal Levels of PGC-1Î± and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise. Cell Metab. 2017;25:1176-1185.e5 pubmed publisher
western blot; human; 1:10,000; fig 5	van Moorsel D, Hansen J, Havekes B, Scheer F, Jorgensen J, Hoeks J, et al. Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Mol Metab. 2016;5:635-645 pubmed publisher
western blot; rat; loading ...; fig 4b	Ogasawara R, Fujita S, Hornberger T, Kitaoka Y, Makanae Y, Nakazato K, et al. The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Sci Rep. 2016;6:31142 pubmed publisher
western blot; human; 1:500; loading ...; fig 2	Wawrzyniak N, Joseph A, Levin D, Gundermann D, Leeuwenburgh C, Sandesara B, et al. Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle. Oncotarget. 2016;7:52695-52709 pubmed publisher
western blot; rat; fig 5	Huang C, Wang T, Tung Y, Lin W. Effect of Exercise Training on Skeletal Muscle SIRT1 and PGC-1? Expression Levels in Rats of Different Age. Int J Med Sci. 2016;13:260-70 pubmed publisher

product information

Catalog Number :

516557-100UL

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-PGC-1, C-Terminal (777-797) Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

10891 (Hu), 19017 (Ms), 83516 (Rt)

Host Name :

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-PGC-1, C-Terminal (777-797) Rabbit pAb

Cross Reactivity :

Human, Mouse

Background :

PGC-1 (PPARɣ-coactivator-1) is a coactivator that promotes transcription through the formation of a complex that includes steroid receptor coactivator-1 (SRC-1) and CREB binding protein (CBP)/p300. The binding of PGC-1 to the hinge domain of PPAR (peroxisome proliferator activated receptor) stimulates a conformational change in PGC-1 that permits binding of SRC-1 and CBP/p300, resulting in a large increase in transcriptional activity. Murine PGC-1 has been also reported to enhance the expression of uncoupling protein-1.

ALT Names :

A830037N07RIK, LEM6, PGC-1, PGC-1(alpha), Pgc-1alpha-a, PGC-1v, PGC1 ALPHA, PGC1A, PGCO1, PPARGC-1 alpha, PPARGC1, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Immunogen :

a synthetic peptide [(C)SKYDSLDFDSLLKEAQRSLRR] corresponding to amino acids 777-797 of the human PPARɣ Coactivator 1 protein

Specificity :

Recognize the ~92-105 kDa (apparent MW) PGC-1 protein.

Package Size :

100 uL

Uses :

ELISA, WB, IH

Storage :

Following initial thaw, aliquot and freeze (-70°C). Avoid repeated freeze-thaw.