Mannose 6-Phosphate Receptor Mouse mAb (2G11) | EMD Millipore 444105-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Mannose 6-Phosphate Receptor Mouse mAb (2G11)

catalog :

444105-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 7b	Hirst J, Edgar J, Esteves T, Darios F, Madeo M, Chang J, et al. Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease. Hum Mol Genet. 2015;24:4984-96 pubmed publisher

product information

Catalog Number :

444105-100UG

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-Mannose 6-Phosphate Receptor Mouse mAb (2G11)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

4074 (Hu), 17113 (Ms), 312689 (Rt)

Host Name :

Clone :

2G11

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-Mannose 6-Phosphate Receptor Mouse mAb (2G11)

Cross Reactivity :

Bovine, Human, Monkey

Background :

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of ~300 kDa cation-independent MPRs. The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPRs is predominantly late endosomes, fewer in the trans Golgi network, and ~10% at cell surface. In addition to its man6P binding activity, MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously.

ALT Names :

CD-MPR, FLJ32994, Mannose-6-phosphate receptor, MGC140730, MGC94300, MPR, MPR46, SMPR, mannose-6-phosphate receptor (cation dependent)

Immunogen :

native bovine cation independent (CI)-mannose 6-phosphate receptor

Specificity :

Recognizes the mannose 6-phosphate receptor protein.

Package Size :

100 ug

Uses :

WB, IF, IH, IP

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.