KDEL Mouse mAb (10C3) | EMD Millipore 420400-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

KDEL Mouse mAb (10C3)

catalog :

420400-50UG

quantity :

50 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

420400-50UG

Category :

Antibodies

Subcategory :

Cell Structure

Product Name :

Anti-KDEL Mouse mAb (10C3)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

3309 (Hu), 14828 (Ms), 25617 (Rt)

Host Name :

Clone :

10C3

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-KDEL Mouse mAb (10C3)

Cross Reactivity :

Canine, drosophila , Guinea Pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep, Yeast

Background :

Several resident proteins in the ER are involved in the proper assembly and folding of newly synthesized proteins. These include the glucose-regulated protein 94 (Grp94), BiP, which functions in protein oligomerization, and protein disulfide isomerase (PDI), which catalyzes the rearrangement of the disulfide bond. Grp94, BiP, and PDI share a carboxy-terminal sequence (Lys-Asp-Glu-Leu) with other resident ER proteins. The KDEL sequence is sufficient for the retention of a protein in the ER.

ALT Names :

78kDa, BIP, GRP78, HEAT SHOCK 70KDA PROTEIN5, Hsce70, HSP70-5, Immunoglobulin heavy chain binding, mBiP, MIF2, SEZ-7, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

Immunogen :

a synthetic peptide (SEKDEL) corresponding to amino acids 649-654 of rat Grp78, conjugated to KLH

Specificity :

Recognizes the KDEL Grp78 (BiP) and Grp94 proteins.

Package Size :

50 ug

Uses :

WB, IC, IP

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.