InSolution™ GSK-3 Inhibitor XVI, CHIR99021 | EMD Millipore 361571-5MG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

chemical

product name :

InSolution™ GSK-3 Inhibitor XVI, CHIR99021

catalog :

361571-5MG

quantity :

5 MG

product information

Catalog Number :

361571-5MG

Subcategory :

Phosphorylation & Dephosphorylation

Product Name :

InSolution™ GSK-3 Inhibitor XVI, CHIR99021

Product Type :

Inhibitors

Product Description :

InSolution™ GSK-3 Inhibitor XVI, CHIR99021

Background :

A cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC 50 = 10 and 6.7 nM against GSK-3alpha and GSK-3beta, respectively). Exhibits little or no activity toward 46 other enzymes (IC 50 8.8 uM against 20 kinases and K i 5 uM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (K d ~4 uM). This compound is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo. The solid form of this compound (Cat. No. 361559) is also available.

ALT Names :

6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile

Purity :

≥95% by HPLC

Package Size :

5 MG