Ezrin Inhibitor, NSC668394 | EMD Millipore 341216-10MG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

chemical

product name :

Ezrin Inhibitor, NSC668394

catalog :

341216-10MG

quantity :

10 MG

product information

Category :

Other Inhibitors

Catalog Number :

341216-10MG

Product Name :

Ezrin Inhibitor, NSC668394

Product Type :

Inhibitors

Product Description :

Ezrin Inhibitor, NSC668394

Background :

A cell-permeable, quinoline that binds directly to ezrin (K d = 12.6 uM) in a reversible manner, and inhibits PKC -mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 uM) and ezrin-actin binding, in vitro . It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 uM. At 10 uM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 uM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vitro at 2.26 mg/kg/day.

ALT Names :

7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione

Specificity :

Reddish orange solid. Packaged under inert gas.

Purity :

≥95% by HPLC

Package Size :

10 MG

Storage :

-20°C. Protect from light. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.