Cytoplasmic Dynein Inhibitor, Ciliobrevin D Calbiochem 10 MG | EMD Millipore 250401-10MG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

chemical

product name :

Cytoplasmic Dynein Inhibitor, Ciliobrevin D Calbiochem 10 MG

catalog :

250401-10MG

quantity :

10 MG

product information

Category :

Cell Signaling

Catalog Number :

250401-10MG

Product Name :

Cytoplasmic Dynein Inhibitor, Ciliobrevin D Calbiochem 10 MG

Product Type :

Inhibitors

Product Description :

Cytoplasmic Dynein Inhibitor, Ciliobrevin D Calbiochem 10 MG

Background :

A cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10 to 40 uM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling.

ALT Names :

2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile, AAA+ ATPase motor cytoplasmic dynein inhibitor

Specificity :

Brown solid. Packaged under inert gas.

Purity :

≥95% by HPLC

Package Size :

10 MG

Storage :

-20°C. Protect from light. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.