ChIPAb+™ N-CoR Antibody | EMD Millipore 17-10260 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ChIPAb+™ N-CoR Antibody

catalog :

17-10260

quantity :

25 assays

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, chromatin immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; loading ...; fig st3 western blot; human; loading ...; fig st3	Gwak J, Shin J, Lee K, Hong S, Oh S, Goh S, et al. SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell migration and invasion in prostate cancer cells. Oncotarget. 2016;7:48250-48264 pubmed publisher

product information

Catalog Number :

17-10260

Subcategory :

Epigenetics & Nuclear Function

Product Name :

ChIPAb+™ N-CoR Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q60974.

Host Name :

Rabbit

Antigen :

N-CoR

Conjugate :

Affinity Purified

Product Description :

ChIPAb+™ N-CoR Antibody

Cross Reactivity :

Human;Mouse

Background :

In the absence of ligands, the corepressor N-CoR represses nuclear hormone receptor-mediated gene transcription. In the presence of ligands, these hormone receptors activate gene expression and play critical roles in development, growth, and homeostasis. N-Cor-mediated transcriptional repression is facilitated through the formation of histone deacetylase (HDACs) N-CoR complexes or by conjugation from small ubiquitin-like modifier 1 (SUMO-1). It is shown that the SANT1 domain of N-CoR serves as a binding region for SUMO-E2 conjugating enzyme Ubc9 and SUMO-E3 ligase Pias1, which is necessary for N-CoR-mediated repression of respective reporter genes. SUMOylation-deficient N-COR knockout mice display a signification reduction in the repression of gene transcription and result in defects involving the differentiation and development of neural cells into erythrocytes and thymocytes.

ALT Names :

Nuclear receptor corepressor 1;N-CoR;N-CoR1;Retinoid X receptor-interacting protein 13

Immunogen :

KLH-conjugated linear peptide corresponding to a region between amino acids 1510 and 1540 of the N-CoR protein.

Package Size :

25 assays

Uses :

Western Blotting;Chromatin Immunoprecipitation (ChIP)

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.