ChIPAb+™ HDAC2 - ChIP Validated Antibody and Primer Set | EMD Millipore 17-10237 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ChIPAb+™ HDAC2 - ChIP Validated Antibody and Primer Set

catalog :

17-10237

quantity :

25 assays

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; 5 ul/mg; fig 8	Su S, Zhao Q, He C, Huang D, Liu J, Chen F, et al. miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nat Commun. 2015;6:8523 pubmed publisher
chromatin immunoprecipitation; human; fig 5	Plotkin A, Volmar C, Wahlestedt C, AYAD N, El Ashry D. Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs. Breast Cancer Res Treat. 2014;147:249-63 pubmed publisher
western blot; mouse; 1:2000	Huang S, Scruggs A, Donaghy J, Horowitz J, Zaslona Z, Przybranowski S, et al. Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts. Cell Death Dis. 2013;4:e621 pubmed publisher

product information

Catalog Number :

17-10237

Subcategory :

Epigenetics & Nuclear Function

Product Name :

ChIPAb+™ HDAC2 - ChIP Validated Antibody and Primer Set

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q92769

Host Name :

Mouse

Antigen :

HDAC2

Conjugate :

Purified

Isotype :

IgG1

Product Description :

ChIPAb+™ HDAC2 - ChIP Validated Antibody and Primer Set

Cross Reactivity :

Human;Bovine;Mouse;Rat;Hamster

Background :

Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly conserved from yeast to human.

ALT Names :

YY1-associated factor 1;histone deacetylase 2;transcriptional regulator homolog RPD3

Immunogen :

KLH-conjugated, synthetic peptide (CEKTDTKGTKSEQLSNP) corresponding to human HDAC2 at the C-terminus.

Specificity :

This antibody recognizes HDAC2 at the C-terminus.

Package Size :

25 assays

Uses :

Western Blotting;Chromatin Immunoprecipitation (ChIP)

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.