ChIPAb+ TCF-4 - ChIP Validated Antibody and Primer Set | EMD Millipore 17-10109 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ChIPAb+ TCF-4 - ChIP Validated Antibody and Primer Set

catalog :

17-10109

quantity :

25 assays

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, EMSA, chromatin immunoprecipitation, immunohistochemistry - frozen section

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 1d	Duncan A, Heyer M, Ishikawa M, Caligiuri S, Liu X, Chen Z, et al. Habenular TCF7L2 links nicotine addiction to diabetes. Nature. 2019;574:372-377 pubmed publisher
chromatin immunoprecipitation; human; fig 6	Katoh I, Fukunishi N, Fujimuro M, Kasai H, Moriishi K, Hata R, et al. Repression of Wnt/Î²-catenin response elements by p63 (TP63). Cell Cycle. 2016;15:699-710 pubmed publisher
western blot; human; 1:1000; loading ...; fig S3A	Pai P, Rachagani S, Lakshmanan I, Macha M, Sheinin Y, Smith L, et al. The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. Mol Oncol. 2016;10:224-39 pubmed publisher
	Melnik S, Dvornikov D, Muller Decker K, Depner S, Stannek P, Meister M, et al. Cancer cell specific inhibition of Wnt/?-catenin signaling by forced intracellular acidification. Cell Discov. 2018;4:37 pubmed publisher
	Saponaro C, Sergio S, Coluccia A, De Luca M, La Regina G, Mologni L, et al. β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. Oncogene. 2018;37:3301-3316 pubmed publisher
	Behari J, Li H, Liu S, Stefanovic Racic M, Alonso L, O Donnell C, et al. ?-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice. Am J Pathol. 2014;184:3284-98 pubmed publisher

product information

Catalog Number :

17-10109

Subcategory :

Epigenetics & Nuclear Function

Product Name :

ChIPAb+ TCF-4 - ChIP Validated Antibody and Primer Set

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9NQB0

Host Name :

Mouse

Antigen :

TCF-4

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

ChIPAb+ TCF-4 - ChIP Validated Antibody and Primer Set

Cross Reactivity :

Human;Mouse

Background :

TCF4, also known as TCF7L2, is expressed widely during development. Gene targeting study indicates that it is required to maintain the crypt stem cells of the small intestine. TCF4 has many different splicing isoforms and they are expressed differentially in tissues and in cancers of different stages. Studies also indicate that variant of the TCF4 gene confers an increased risk of type 2 diabetes.

ALT Names :

HMG box transcription factor 4;Transcription factor 7-like 2;T-Cell factor 4;T-cell-specific, HMG box;T-Cell-specific transcription factor 4;Transcription factor 7-like 2

Immunogen :

Amino acids 31-331 of human TCF-4.

Specificity :

This antibody recognizes TCF-4

Package Size :

25 assays

Uses :

Western Blotting;Dot Blot;Chromatin Immunoprecipitation (ChIP)

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.