ChIPAb+ Histone H2A.Z - ChIP Validated Antibody and Primer Set | EMD Millipore 17-10048 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ChIPAb+ Histone H2A.Z - ChIP Validated Antibody and Primer Set

catalog :

17-10048

quantity :

25 assays

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, zebrafish

application :

western blot, chromatin immunoprecipitation

product information

Catalog Number :

17-10048

Subcategory :

Epigenetics & Nuclear Function

Product Name :

ChIPAb+ Histone H2A.Z - ChIP Validated Antibody and Primer Set

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P0C0S5

Host Name :

Sheep

Antigen :

Histone H2A.Z

Conjugate :

Affinity Purified

Product Description :

ChIPAb+ Histone H2A.Z - ChIP Validated Antibody and Primer Set

Cross Reactivity :

Human

Background :

H2A.Z, also known as H2AFZ, is a variant of histone H2A variant that is highly conserved from yeast to humans. Like other histone variants, H2A.Z is encoded by a unique gene, resulting in a slightly divergent type of H2A with specialized functions. H2A.Z is involved in chromatin compaction by stabilizing the histone octamer within the nucleosome. It promotes gene expression through the creation of an open domain of chromatin that is more easily transcribed. H2A.Z is nonrandomly distributed throughout the genome, targeted primarily to pericentric heterochromatin, but excluded from the inactive X chromosome and the nucleolus. H2A.Z is associated with both euchromatin and facultative heterochromatin. DNA methylation can influence chromatin structure and effect gene silencing by excluding H2A.Z, and likewise, H2A.Z protects genes from DNA methylation. Thus, H2A.Z plays a role in regulating heterochromatin silencing and is involved in transcriptional control.

ALT Names :

H2A histone family, member Z;H2AZ histone

Immunogen :

Linear peptide corresponding the C-terminal amino acids 113-127 of human Histone H2A.Z.

Specificity :

Recognizes Histone H2A.Z, Mr ~15 kDa.

Package Size :

25 assays

Uses :

Chromatin Immunoprecipitation (ChIP);Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.