This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, FITC conjugate
catalog :
16-202A
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
FITC
antigen modification :
phosphorylated
clone name :
JBW301
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 109
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s5
Ding D, Liu J, Dong K, Melnick A, Latham K, Chen C. Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis. Nucleic Acids Res. 2019;47:2594-2608 pubmed publisher
  • immunocytochemistry; mouse
Ghazaryan S, Sy C, Hu T, An X, Mohandas N, Fu H, et al. Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation. Mol Cell Biol. 2014;34:2833-47 pubmed publisher
Chernikova S, Nguyen R, Truong J, Mello S, Stafford J, Hay M, et al. Dynamin impacts homology-directed repair and breast cancer response to chemotherapy. J Clin Invest. 2018;128:5307-5321 pubmed publisher
Bai S, Fu K, Yin H, Cui Y, Yue Q, Li W, et al. Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes. Development. 2018;145: pubmed publisher
Shi B, Xue J, Zhou J, Kasowitz S, Zhang Y, Liang G, et al. MORC2B is essential for meiotic progression and fertility. PLoS Genet. 2018;14:e1007175 pubmed publisher
Li Z, Wang H, Wang Y, Murnane J, Dynan W. Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells. Radiat Res. 2014;182:573-9 pubmed publisher
Ishiguro K, Lin Z, Penketh P, Shyam K, Zhu R, Baumann R, et al. Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes. Biochem Pharmacol. 2014;91:312-22 pubmed publisher
Drutovic D, Chripkova M, Pilatova M, Kruzliak P, Perjesi P, Sarissky M, et al. Benzylidenetetralones, cyclic chalcone analogues, induce cell cycle arrest and apoptosis in HCT116 colorectal cancer cells. Tumour Biol. 2014;35:9967-75 pubmed publisher
Znojek P, Willmore E, Curtin N. Preferential potentiation of topoisomerase I poison cytotoxicity by PARP inhibition in S phase. Br J Cancer. 2014;111:1319-26 pubmed publisher
Manguan García C, Pintado Berninches L, Carrillo J, Machado Pinilla R, Sastre L, Perez Quilis C, et al. Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells. PLoS ONE. 2014;9:e101424 pubmed publisher
Samuni Y, Wink D, Krishna M, Mitchell J, Goldstein S. Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide. Free Radic Biol Med. 2014;73:291-8 pubmed publisher
Patterson M, Sutton R, Forrest I, Sharrock R, Lane M, Kaufmann A, et al. Assessing the function of homologous recombination DNA repair in malignant pleural effusion (MPE) samples. Br J Cancer. 2014;111:94-100 pubmed publisher
Shahar O, Kalousi A, Eini L, Fisher B, Weiss A, Darr J, et al. A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair. Nucleic Acids Res. 2014;42:5689-701 pubmed publisher
Chang H, Wang H, Chen C, Hung T, Hou M, Yuan S, et al. 5-azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells. Molecules. 2014;19:3149-59 pubmed publisher
Bokobza S, Jiang Y, Weber A, Devery A, Ryan A. Short-course treatment with gefitinib enhances curative potential of radiation therapy in a mouse model of human non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2014;88:947-54 pubmed publisher
Ramaekers C, van den Beucken T, Bristow R, Chiu R, Durocher D, Wouters B. RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage. PLoS ONE. 2014;9:e89997 pubmed publisher
Petrova N, Velichko A, Kantidze O, Razin S. Heat shock-induced dissociation of TRF2 from telomeres does not initiate a telomere-dependent DNA damage response. Cell Biol Int. 2014;38:675-81 pubmed publisher
Islam M, Thomas S, Murty V, Sedoris K, Miller D. c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA. J Biol Chem. 2014;289:8521-31 pubmed publisher
Ferlazzo M, Sonzogni L, Granzotto A, Bodgi L, Lartin O, Devic C, et al. Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates. Mol Neurobiol. 2014;49:1200-11 pubmed publisher
Vitale N, Kisslinger A, Paladino S, Procaccini C, Matarese G, Pierantoni G, et al. Resveratrol couples apoptosis with autophagy in UVB-irradiated HaCaT cells. PLoS ONE. 2013;8:e80728 pubmed publisher
Di Francesco A, De Pittà C, Moret F, Barbieri V, Celotti L, Mognato M. The DNA-damage response to ?-radiation is affected by miR-27a in A549 cells. Int J Mol Sci. 2013;14:17881-96 pubmed publisher
Vavrova J, Zarybnicka L, Lukasova E, Rezacova M, Novotna E, Sinkorova Z, et al. Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60). Radiat Environ Biophys. 2013;52:471-9 pubmed publisher
Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, et al. Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model. Thyroid. 2014;24:502-10 pubmed publisher
Wells C, Bhaskara S, Stengel K, Zhao Y, Sirbu B, Chagot B, et al. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS ONE. 2013;8:e68915 pubmed publisher
Bee L, Fabris S, Cherubini R, Mognato M, Celotti L. The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression. PLoS ONE. 2013;8:e69061 pubmed publisher
Streppel M, Pai S, Campbell N, Hu C, Yabuuchi S, Canto M, et al. MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1. Clin Cancer Res. 2013;19:4067-78 pubmed publisher
Millet P, Granotier C, Etienne O, Boussin F. Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines. Int J Oncol. 2013;43:375-82 pubmed publisher
Li Z, Hudson F, Wang H, Wang Y, Bian Z, Murnane J, et al. Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiat Res. 2013;180:17-24 pubmed publisher
Ryu S, Kawamura R, Naka R, Silberberg Y, Nakamura N, Nakamura C. Nanoneedle insertion into the cell nucleus does not induce double-strand breaks in chromosomal DNA. J Biosci Bioeng. 2013;116:391-6 pubmed publisher
Muller I, Merk B, Voss K, Averbeck N, Jakob B, Durante M, et al. Species conserved DNA damage response at the inactive human X chromosome. Mutat Res. 2013;756:30-6 pubmed publisher
Sorokina S, Markova E, Gursky J, Dobrovodsky J, Belyaev I. Relative biological efficiency of protons at low and therapeutic doses in induction of 53BP1/?H2AX foci in lymphocytes from umbilical cord blood. Int J Radiat Biol. 2013;89:716-23 pubmed publisher
Lu X, Parvathaneni S, Hara T, Lal A, Sharma S. Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D. Mol Cancer. 2013;12:29 pubmed publisher
Berchtold C, Coughlin A, Kasper Z, Thibeault S. Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction. Laryngoscope. 2013;123:2228-36 pubmed publisher
Jha H, Upadhyay S, A J Prasad M, Lu J, Cai Q, Saha A, et al. H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence. J Virol. 2013;87:5255-69 pubmed publisher
Fischer B, Wong J, Degan S, Kummarapurugu A, Zheng S, Haridass P, et al. Increased expression of senescence markers in cystic fibrosis airways. Am J Physiol Lung Cell Mol Physiol. 2013;304:L394-400 pubmed publisher
Konishi T, Oikawa M, Suya N, Ishikawa T, Maeda T, Kobayashi A, et al. SPICE-NIRS microbeam: a focused vertical system for proton irradiation of a single cell for radiobiological research. J Radiat Res. 2013;54:736-47 pubmed publisher
Montenegro M, Sáez Ayala M, Piñero Madrona A, Cabezas Herrera J, Rodriguez Lopez J. Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation. PLoS ONE. 2012;7:e52231 pubmed publisher
Subramanian C, Hada M, Opipari A, Castle V, Kwok R. CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma. Mol Cancer Res. 2013;11:173-81 pubmed publisher
Xiao Y, Wang J, Song H, Zou P, Zhou D, Liu L. CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence. Leuk Res. 2013;37:333-40 pubmed publisher
Tsai Y, Yeh C, Tzen K, Ho P, Tuan T, Pu Y, et al. Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma. Eur J Cancer. 2013;49:1458-66 pubmed publisher
Conradt L, Henrich A, Wirth M, Reichert M, Lesina M, Algül H, et al. Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death. Int J Cancer. 2013;132:2248-57 pubmed publisher
Solarczyk K, Zarebski M, Dobrucki J. Inducing local DNA damage by visible light to study chromatin repair. DNA Repair (Amst). 2012;11:996-1002 pubmed publisher
Gallagher S, Kofman A, Huszar J, Dannenberg J, Depinho R, Braun R, et al. Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. Dev Biol. 2013;373:83-94 pubmed publisher
Coffey K, Blackburn T, Cook S, Golding B, Griffin R, Hardcastle I, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS ONE. 2012;7:e45539 pubmed publisher
Arango D, Parihar A, Villamena F, Wang L, Freitas M, Grotewold E, et al. Apigenin induces DNA damage through the PKC?-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. Biochem Pharmacol. 2012;84:1571-80 pubmed publisher
Li Y, Xiong H, Yang D. Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells. Chin J Cancer. 2012;31:364-72 pubmed publisher
Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed publisher
Xiao Y, Zou P, Wang J, Song H, Zou J, Liu L. Lower phosphorylation of p38 MAPK blocks the oxidative stress-induced senescence in myeloid leukemic CD34(+)CD38 (-) cells. J Huazhong Univ Sci Technolog Med Sci. 2012;32:328-333 pubmed publisher
Kudo T, Ikeda M, Nishikawa M, Yang Z, Ohno K, Nakagawa K, et al. The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53. Cancer Res. 2012;72:2901-11 pubmed publisher
Duxin J, Moore H, Sidorova J, Karanja K, Honaker Y, Dao B, et al. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem. 2012;287:21980-91 pubmed publisher
Thiemann M, Oertel S, Ehemann V, Weichert W, Stenzinger A, Bischof M, et al. In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model. Radiat Oncol. 2012;7:52 pubmed publisher
Sergent J, Paget V, Chevillard S. Toxicity and genotoxicity of nano-SiO2 on human epithelial intestinal HT-29 cell line. Ann Occup Hyg. 2012;56:622-30 pubmed publisher
Sultana R, McNeill D, Abbotts R, Mohammed M, Zdzienicka M, Qutob H, et al. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors. Int J Cancer. 2012;131:2433-44 pubmed publisher
Brzozowska K, Pinkawa M, Eble M, Müller W, Wojcik A, Kriehuber R, et al. In vivo versus in vitro individual radiosensitivity analysed in healthy donors and in prostate cancer patients with and without severe side effects after radiotherapy. Int J Radiat Biol. 2012;88:405-13 pubmed publisher
Runge R, Hiemann R, Wendisch M, Kasten Pisula U, Storch K, Zophel K, et al. Fully automated interpretation of ionizing radiation-induced ?H2AX foci by the novel pattern recognition system AKLIDES®. Int J Radiat Biol. 2012;88:439-47 pubmed publisher
Algire C, Moiseeva O, Deschênes Simard X, Amrein L, Petruccelli L, Birman E, et al. Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res (Phila). 2012;5:536-43 pubmed publisher
Spagnolo L, Barbeau J, Curtin N, Morris E, Pearl L. Visualization of a DNA-PK/PARP1 complex. Nucleic Acids Res. 2012;40:4168-77 pubmed publisher
Ting H, Yasmin Karim S, Yan S, Hsu J, Lin T, Zeng W, et al. A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. Cancer Res. 2012;72:958-68 pubmed publisher
Moraes M, de Andrade A, Carvalho H, Guecheva T, Agnoletto M, Henriques J, et al. Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions. Cancer Lett. 2012;314:108-18 pubmed publisher
Lin R, Zhou N, Lyu Y, Tsai Y, Lu C, Kerrigan J, et al. Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase II?. J Biol Chem. 2011;286:33591-600 pubmed publisher
Bridges K, Hirai H, Buser C, Brooks C, Liu H, Buchholz T, et al. MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Clin Cancer Res. 2011;17:5638-48 pubmed publisher
Dittmann K, Mayer C, Fehrenbacher B, Schaller M, Kehlbach R, Rodemann H. Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access. Radiother Oncol. 2011;99:317-22 pubmed publisher
Di Giacomo F, Granotier C, Barroca V, Laurent D, Boussin F, Lewandowski D, et al. Tritium contamination of hematopoietic stem cells alters long-term hematopoietic reconstitution. Int J Radiat Biol. 2011;87:556-70 pubmed publisher
Castillo P, Bogliolo M, Surralles J. Coordinated action of the Fanconi anemia and ataxia telangiectasia pathways in response to oxidative damage. DNA Repair (Amst). 2011;10:518-25 pubmed publisher
Pazhanisamy S, Li H, Wang Y, Batinic Haberle I, Zhou D. NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability. Mutagenesis. 2011;26:431-5 pubmed publisher
Benatti P, Dolfini D, Vigano A, Ravo M, Weisz A, Imbriano C. Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Nucleic Acids Res. 2011;39:5356-68 pubmed publisher
Zhuang W, Li B, Long L, Chen L, Huang Q, Liang Z. Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. Int J Cancer. 2011;129:2720-31 pubmed publisher
Ye W, Blain S. Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage. Apoptosis. 2011;16:449-59 pubmed publisher
Zhang Y, Regairaz M, Seiler J, Agama K, Doroshow J, Pommier Y. Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res. 2011;39:3607-20 pubmed publisher
Zhang K, Wu J, Wu X, Wang X, Wang Y, Zhou N, et al. p53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest. Mol Cancer Ther. 2011;10:269-78 pubmed publisher
Hill J, Tansavatdi K, Lockett K, Allen G, Takita C, Pollack A, et al. Validation of the cell cycle G(2) delay assay in assessing ionizing radiation sensitivity and breast cancer risk. Cancer Manag Res. 2009;1:39-48 pubmed
Rothkamm K, Burdak Rothkamm S. Ionizing radiation-induced DNA strand breaks and ?-H2AX?-H2AX foci in cells exposed to nitric oxide. Methods Mol Biol. 2011;704:17-25 pubmed publisher
Elliott S, Crawford C, Mulligan E, Summerfield G, Newton P, Wallis J, et al. Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia. Br J Haematol. 2011;152:61-71 pubmed publisher
Nykky J, Tuusa J, Kirjavainen S, Vuento M, Gilbert L. Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine. Int J Nanomedicine. 2010;5:417-28 pubmed
Landsverk H, Mora Bermúdez F, Landsverk O, Hasvold G, Naderi S, Bakke O, et al. The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response. EMBO Rep. 2010;11:868-75 pubmed publisher
Kuck D, Caulfield T, Lyko F, Medina Franco J. Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells. Mol Cancer Ther. 2010;9:3015-23 pubmed publisher
Audebert M, Riu A, Jacques C, Hillenweck A, Jamin E, Zalko D, et al. Use of the ?H2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines. Toxicol Lett. 2010;199:182-92 pubmed publisher
Nelson A, Holt J. Impact of RING and BRCT domain mutations on BRCA1 protein stability, localization and recruitment to DNA damage. Radiat Res. 2010;174:1-13 pubmed publisher
Ye W, Blain S. S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons. Brain. 2010;133:2295-312 pubmed publisher
Carlessi L, Buscemi G, Fontanella E, Delia D. A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage. Biochim Biophys Acta. 2010;1803:1213-23 pubmed publisher
Mukhopadhyay A, Elattar A, Cerbinskaite A, Wilkinson S, Drew Y, Kyle S, et al. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clin Cancer Res. 2010;16:2344-51 pubmed publisher
Le O, Rodier F, Fontaine F, Coppe J, Campisi J, DeGregori J, et al. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell. 2010;9:398-409 pubmed publisher
Mitchell J, Choudhuri R, Fabre K, Sowers A, Citrin D, Zabludoff S, et al. In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762. Clin Cancer Res. 2010;16:2076-84 pubmed publisher
Soule B, Simone N, DeGraff W, Choudhuri R, Cook J, Mitchell J. Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines. Radiat Oncol. 2010;5:8 pubmed publisher
Glauser D, Seyffert M, Strasser R, Franchini M, Laimbacher A, Dresch C, et al. Inhibition of herpes simplex virus type 1 replication by adeno-associated virus rep proteins depends on their combined DNA-binding and ATPase/helicase activities. J Virol. 2010;84:3808-24 pubmed publisher
Belzile J, Richard J, Rougeau N, Xiao Y, Cohen E. HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest. J Virol. 2010;84:3320-30 pubmed publisher
Pospelova T, Demidenko Z, Bukreeva E, Pospelov V, Gudkov A, Blagosklonny M. Pseudo-DNA damage response in senescent cells. Cell Cycle. 2009;8:4112-8 pubmed
Wang Y, Liu L, Pazhanisamy S, Li H, Meng A, Zhou D. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol Med. 2010;48:348-56 pubmed publisher
Bauerschmidt C, Arrichiello C, Burdak Rothkamm S, Woodcock M, Hill M, Stevens D, et al. Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin. Nucleic Acids Res. 2010;38:477-87 pubmed publisher
Wilson P, Nham P, Urbin S, Hinz J, Jones I, Thompson L. Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation. Mutat Res. 2010;683:91-7 pubmed publisher
Ciccia A, Bredemeyer A, Sowa M, Terret M, Jallepalli P, Harper J, et al. The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev. 2009;23:2415-25 pubmed publisher
Msiska Z, Pacurari M, Mishra A, Leonard S, Castranova V, Vallyathan V. DNA double-strand breaks by asbestos, silica, and titanium dioxide: possible biomarker of carcinogenic potential?. Am J Respir Cell Mol Biol. 2010;43:210-9 pubmed publisher
Cook J, Choudhuri R, DeGraff W, Gamson J, Mitchell J. Halofuginone enhances the radiation sensitivity of human tumor cell lines. Cancer Lett. 2010;289:119-26 pubmed publisher
Simonnet A, Nehme J, Vaigot P, Barroca V, Leboulch P, Tronik Le Roux D. Phenotypic and functional changes induced in hematopoietic stem/progenitor cells after gamma-ray radiation exposure. Stem Cells. 2009;27:1400-9 pubmed publisher
Zarebski M, Wiernasz E, Dobrucki J. Recruitment of heterochromatin protein 1 to DNA repair sites. Cytometry A. 2009;75:619-25 pubmed publisher
Nichols G, Schaack J, Ornelles D. Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. J Virol. 2009;83:5987-98 pubmed publisher
Golding S, Morgan R, Adams B, Hawkins A, Povirk L, Valerie K. Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells. Cancer Biol Ther. 2009;8:730-8 pubmed
Carlessi L, De Filippis L, Lecis D, Vescovi A, Delia D. DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression. Cell Death Differ. 2009;16:795-806 pubmed publisher
Parsels L, Morgan M, Tanska D, Parsels J, Palmer B, Booth R, et al. Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells. Mol Cancer Ther. 2009;8:45-54 pubmed publisher
Kasten Pisula U, Menegakis A, Brammer I, Borgmann K, Mansour W, Degenhardt S, et al. The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair. Radiother Oncol. 2009;90:257-64 pubmed publisher
Perotti C, Liu R, Parusel C, Böcher N, Schultz J, Bork P, et al. Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation. Breast Cancer Res. 2008;10:R94 pubmed publisher
Eliezer Y, Argaman L, Rhie A, Doherty A, Goldberg M. The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage. J Biol Chem. 2009;284:426-35 pubmed publisher
Enokido Y, Yoshitake A, Ito H, Okazawa H. Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain. Biochem Biophys Res Commun. 2008;376:128-33 pubmed publisher
Muslimovic A, Ismail I, Gao Y, Hammarsten O. An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells. Nat Protoc. 2008;3:1187-93 pubmed publisher
Burgess D, Doles J, Zender L, Xue W, Ma B, McCombie W, et al. Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci U S A. 2008;105:9053-8 pubmed publisher
Vuyyuri S, Hamstra D, Khanna D, Hamilton C, Markwart S, Campbell K, et al. Evaluation of D-methionine as a novel oral radiation protector for prevention of mucositis. Clin Cancer Res. 2008;14:2161-70 pubmed publisher
Al Ejeh F, Darby J, Brown M. The La autoantigen is a malignancy-associated cell death target that is induced by DNA-damaging drugs. Clin Cancer Res. 2007;13:5509s-5518s pubmed
Kotsopoulos J, Chen Z, Vallis K, Poll A, Ainsworth P, Narod S. DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers. Br J Cancer. 2007;96:118-25 pubmed
Rose J, Reeves K, Likhotvorik R, Hoyt D. Base excision repair proteins are required for integrin-mediated suppression of bleomycin-induced DNA breakage in murine lung endothelial cells. J Pharmacol Exp Ther. 2007;321:318-26 pubmed
product information
Catalog Number :
16-202A
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, FITC conjugate
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P16104
Host Name :
Mouse
Antigen :
phospho-Histone H2A.X (Ser139)
Clone :
clone JBW301
Conjugate :
Purified
Isotype :
IgG1
Product Description :
Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, FITC conjugate
Cross Reactivity :
Human
Background :
Histone H2A is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H2A is involved with the structure of the nucleosomes of the 'beads on a string' structure.
ALT Names :
H2AXS139P;Histone H2A.X (phospho S139);H2A histone family, member X;H2AX histone
Immunogen :
KLH-conjugated, synthetic peptide (CKATQA[pS]QEY) corresponding to amino acids 134-142 of human histone H2A.X. The immunizing sequence has 8 identical amino acids in yeast and mouse. Clone JBW301.
Specificity :
Recognizes Histone H2A.X phosphorylated at Ser139, MW 15 kDa.
Package Size :
100 μg
Uses :
Flow Cytometry;Immunocytochemistry
Storage :
Stable for 1 year at from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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