IRS1 Antibody, agarose conjugate | EMD Millipore 16-146 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IRS1 Antibody, agarose conjugate

catalog :

16-146

quantity :

200 µg

clonality :

polyclonal

host :

rabbit

conjugate :

agarose

application :

immunoprecipitation

citations: 1

Reference
Weintraub A, Li C, Zamudio A, Sigova A, Hannett N, Day D, et al. YY1 Is a Structural Regulator of Enhancer-Promoter Loops. Cell. 2017;171:1573-1588.e28 pubmed publisher

product information

Catalog Number :

16-146

Subcategory :

Cell Signaling

Product Name :

Anti-IRS1 Antibody, agarose conjugate

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P35568

Host Name :

Rabbit

Antigen :

IRS1

Conjugate :

Gel Immobilized

Isotype :

IgG

Product Description :

Anti-IRS1 Antibody, agarose conjugate

Cross Reactivity :

All

Background :

Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified that differ as to tissue distribution, subcellular localization, developmental expression, binding to the insulin receptor, and interaction with SH2 domain-containing proteins. Results from targeted disruption of the IRS genes in mice have provided important clues to the functional differences among these related molecules, suggesting they play different and specific roles in vivo. The available data are consistent with the notion that IRS-1 and IRS-2 are not functionally interchangeable in tissues that are responsible for glucose production (liver), glucose uptake (skeletal muscle and adipose tissue), and insulin production (pancreatic β cells). In fact, IRS-1 appears to have its major role in skeletal muscle whereas IRS-2 appears to regulate hepatic insulin action as well as pancreatic cell development and survival. By contrast, IRS-3 and IRS-4 genes appear to play a redundant role in the IRS signaling system. Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes.

ALT Names :

insulin receptor substrate 1

Immunogen :

Carboxy-terminal 14 amino acid peptide of rat liver IRS1 (C-YASINFQKQPEDRQ).

Specificity :

Recognizes IRS1, Mr 160-185kDa.

Package Size :

200 µg

Uses :

Immunoprecipitation

Storage :

Stable for 6 months at 2-8ºC from date of receipt.