acetyl Cortactin Antibody | EMD Millipore 09-881 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

acetyl Cortactin Antibody

catalog :

09-881

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; fig 2a	Mo Z, Zhao X, Liu H, Hu Q, Chen X, Pham J, et al. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018;9:1007 pubmed publisher
western blot; human; loading ...; fig 5S1A	Jeannot P, Nowosad A, Perchey R, Callot C, Bennana E, Katsube T, et al. p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. elife. 2017;6: pubmed publisher

product information

Catalog Number :

09-881

Subcategory :

Cell Structure

Product Name :

Anti-acetyl Cortactin Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q14247

Host Name :

Rabbit

Antigen :

acetyl Cortactin

Conjugate :

Affinity Purified

Product Description :

Anti-acetyl Cortactin Antibody

Cross Reactivity :

Human

Background :

Cortactin is a cytoskeleton protein that facilitates assembly of cortical actin. Cortactin is widely expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src in vivo and in vitro. The protein sequence of cortactin contains multiple amino-terminal tandem repeats of a unique 37-amino acid sequence, which associates with actin, and a Src homology 3 domain at the carboxyl terminus. Recent research efforts show cortactin is acetylated in vivo and is deacetylated by HDAC6 (Histone deacetylase 6). HDAC6 is a tubulin-specific deacetylase that regulates microtubule-dependent cell movement. In recent studies it was demonstrated that HDAC6 binds cortactin and alters the ability of cortactin to bind F-actin by modulating a “charge patch” in its repeat region. Findings suggest that, in addition to its role in microtubule-dependent cell motility, HDAC6 influences actin-dependent cell motility by altering the acetylation status of cortactin, which, in turn, changes the F-actin binding activity of cortactin. The acetylation level of cortactin may correlate to tumor metastases and acetylated cortactin may be considered a potential metastasis marker.

ALT Names :

Amplaxin;Oncogene EMS1;Src substrate cortactin

Immunogen :

Consensus sequence motif of acetylation sites of cortactin.

Specificity :

The antibody recognizes human acetylated Cortactin.

Package Size :

100 μg

Uses :

Western Blotting;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt