Methylcytosine dioxygenase TET1 Antibody | EMD Millipore 09-872 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Methylcytosine dioxygenase TET1 Antibody

catalog :

09-872

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, brewer's yeast

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, ChIP-Seq

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 7e	Pan H, Jiang N, Sun S, Jiang H, Xu J, Jiang X, et al. UHRF1-repressed 5'-hydroxymethylcytosine is essential for the male meiotic prophase I. Cell Death Dis. 2020;11:142 pubmed publisher
immunoprecipitation; mouse; fig 5e western blot; mouse; fig 5e	Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, et al. PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency. Stem Cell Reports. 2016;7:1072-1086 pubmed publisher
immunoprecipitation; human; loading ...; fig s8a western blot; human; loading ...; fig s8b ChIP-Seq; mouse; loading ...; tbl s2	Zhong J, Li X, Cai W, Wang Y, Dong S, Yang J, et al. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function. Nucleic Acids Res. 2017;45:672-684 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s2a	Thienpont B, Steinbacher J, Zhao H, D Anna F, Kuchnio A, Ploumakis A, et al. Tumour hypoxia causes DNA hypermethylation by reducing TET activity. Nature. 2016;537:63-68 pubmed publisher
western blot; brewer's yeast; 1:5000; fig 1	Weber A, Krawczyk C, Robertson A, KuÅ›nierczyk A, VÃ¥gbÃ¸ C, Schuermann D, et al. Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun. 2016;7:10806 pubmed publisher
immunohistochemistry; mouse; 1:500	Murakami K, GÃ¼nesdogan U, Zylicz J, Tang W, Sengupta R, Kobayashi T, et al. NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers. Nature. 2016;529:403-407 pubmed publisher
	Burr S, Caldwell A, Chong M, Beretta M, Metcalf S, Hancock M, et al. Oxygen gradients can determine epigenetic asymmetry and cellular differentiation via differential regulation of Tet activity in embryonic stem cells. Nucleic Acids Res. 2018;46:1210-1226 pubmed publisher
	Yosefzon Y, David C, Tsukerman A, Pnueli L, Qiao S, Boehm U, et al. An epigenetic switch repressing Tet1 in gonadotropes activates the reproductive axis. Proc Natl Acad Sci U S A. 2017;114:10131-10136 pubmed publisher

product information

Catalog Number :

09-872

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Methylcytosine dioxygenase TET1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q3URK3

Host Name :

Rabbit

Antigen :

Methylcytosine dioxygenase TET1

Conjugate :

Affinity Purified

Product Description :

Anti-Methylcytosine dioxygenase TET1 Antibody

Cross Reactivity :

Mouse

Background :

Methylcytosine dioxygenase TET1 (mTET1) is a member of the TET family and contains a characteristic CXXC-type zinc finger domain. mTET1 binds methylcytosine (5mC), a minor, mammalian DNA base necessary to development and retrotransposon silencing, and acts as a catalyst to induce the conversion of 5mC to 5-hydromethylcytosine (hmC or 5hmC), a mammalian DNA base thought to be involved in chromatin structure and in the development of fetal brain, heart and lung tissues. Recent studies indicate that mTET1 regulates the levels of 5hmC, thereby influencing patterns in DNA methylation.

ALT Names :

tet oncogene 1;Ten-eleven translocation 1 gene protein;CXXC-type zinc finger protein 6;methylcytosine dioxygenase TET1;CXXC finger 6;ten-eleven translocation-1;Leukemia-associated protein with a CXXC domain

Immunogen :

KLH-conjugated linear peptide corresponding to mouse Methylcytosine dioxygenase TET1 near the C-terminus.

Specificity :

This antibody recognizes methylcytosine dioxygenase TET1 near the C-terminus.

Package Size :

100 μg

Uses :

Western Blotting;ChIP-seq

Storage :

Stable for 1 year at 2-8°C from date of receipt