dimethyl MBP (Arg107) Antibody | EMD Millipore 09-849 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

dimethyl MBP (Arg107) Antibody

catalog :

09-849

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

09-849

Subcategory :

Neuroscience

Product Name :

Anti-dimethyl MBP (Arg107) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P02686

Host Name :

Rabbit

Antigen :

dimethyl MBP (Arg107)

Conjugate :

Serum

Isotype :

IgG

Product Description :

Anti-dimethyl MBP (Arg107) Antibody

Cross Reactivity :

Mouse;Human;Rat

Background :

Myelin basic protein (MBP) is the major extrinsic membrane protein of central nervous system. MBP is believed to be important in the process of myelination of nerves in the central nervous system (CNS). MBP was initially sequenced in 1979 after isolation from myelin membranes. Since that time, knockout mice deficient in MBP have been developed which showed decreased amounts of CNS myelination and a progressive disorder characterized by tremors, seizures, and early death. The gene for MBP is on chromosome 18; the protein localizes to the CNS and to various cells of the hematopoietic system. The pool of MBP in the central nervous system is very diverse. Not only is MBP present in a number of splice varients, but the protein also undergoes a variety of post-translational modifications, and exists in the CNS in a number of forms (i.e. phosphorylated, methylated, deamidated and citrullinated). Interest in MBP has centered on its role in demyelinating diseases, particularly multiple sclerosis (MS). Several studies have shown a role for antibodies against MBP in the pathogenesis of MS. Some studies have linked a genetic predisposition to MS to the MBP gene, though a majority have not.

ALT Names :

myelin basic protein;Golli-mbp;Myelin membrane encephalitogenic protein;Myelin A1 protein, MBP

Immunogen :

KLH-conjugated linear peptide corresponding to the C-terminus of MBP dimethylated at Arg107.

Specificity :

This antibody recognizes MBP dimethylated at Arg107.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.