SIRT2 Antibody | EMD Millipore 09-843 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SIRT2 Antibody

catalog :

09-843

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunoprecipitation, western blot knockout validation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; 1:1000; loading ...; fig 3a	Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta M, et al. SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. elife. 2018;7: pubmed publisher
	Wang S, Ko S, Jo S, Jo H, Han J, Kim Y, et al. Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2. Exp Neurobiol. 2019;28:537-546 pubmed publisher

product information

Catalog Number :

09-843

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-SIRT2 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8IXJ6

Host Name :

Rabbit

Antigen :

SIRT2

Conjugate :

Affinity Purified

Product Description :

Anti-SIRT2 Antibody

Cross Reactivity :

Human;Mouse

Background :

Sirtuins are hypothesized to play a key role in an organism's response to stresses (such as heat or starvation) and to be responsible for the lifespan-extending effects of calorie restriction. Sirtuins act by removing acetyl groups from proteins in the presence of NAD+; they are thus classified as "NAD+-dependent deacetylases". Mammals have seven sirtuins; SIRT1 and SIRT2 occupy the cytoplasm. SIRT2 is a NAD-dependent deacytylase. It has been shown to control gene silencing, cell cycle, and DNA damage repair. In additon, SIRT2 acts as a tumor suppressor in human gliomas which suggests that the ectopic expression of SIRT2 upsets the microtubule network.

ALT Names :

SIR2-like protein 2;silencing information regulator 2-like;silent information regulator 2;sir2-related protein type 2;sirtuin (silent mating type information regulation 2;homolog) 2 (S. cerevisiae) sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2;sirtuin 2;sirtuin type 2

Immunogen :

KLH-conjugated linear peptide corresponding to the mature protein of human SIRT2.

Specificity :

This antibody recognizes the mature protein of SIRT2.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt