PI3 Kinase Antibody, p110α | EMD Millipore 09-481 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PI3 Kinase Antibody, p110α

catalog :

09-481

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation

product information

Catalog Number :

09-481

Subcategory :

Cell Signaling

Product Name :

Anti-PI3 Kinase Antibody, p110α

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P42336

Host Name :

Rabbit

Antigen :

PI3 Kinase

Conjugate :

Affinity Purified

Product Description :

Anti-PI3 Kinase Antibody, p110α

Cross Reactivity :

Human;Rat

Background :

Phosphoinositol-3-kinases (PI3 Kinase, PI3K) are a family of lipid kinases that mediate many intracellular signaling responses in both physiological and pathophysiological states. PI3 Kinase is a heteroduplex with three classes (I, II, & III) of catalytic domain. The class I PI3 Kinases are made up of a p85 regulatory protein and a p110 catalytic domain. There are 4 isoforms of the class I p110 catalytic domains. Class I(A) include α, β, γ and class I(B). They are activated downstream via receptor tyrosine kinases or G-protein coupled receptors. Once activated, PI3K generates phosphatidylinositol 3,4,5-trisphosphate (PIP3) from PIP2. It was later found that PTEN, a lipid phosphatase, acts opposite to PI3K by dephosphorylating PIP3, converting it to PIP2, thus de-activating the effects of PI3K. Increased levels of PIP3 in the cell leads to the activation of many key signaling regulators including Akt and PDK as well as calcium release. One of the primary roles of PI3K is its regulation of cell growth and cell metabolism. Both of these play a critical role in cancer as some believe that a tumor’s shift to glycolysis is due to the activation of PI3K. PI3 kinases have been linked with numerous disease states, including cancer, diabetes, allergic response, hypertension, cardiac contractility, atherosclerosis, sepsis and autoimmune/ inflammatory disorders.

ALT Names :

PI3-kinase p110 subunit alpha ;PtdIns-3-kinase p110 ;phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha ;phosphatidylinositol 3-kinase, catalytic, alpha polypeptide ;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform ;phosphoinositide-3-kinase, catalytic, alpha polypeptide

Immunogen :

KLH-conjugated synthetic linear peptide corresponding to an internal region of class I catalytic domain of PI3 Kinase that is specific to the p110 alpha isoform.

Specificity :

Recognizes PI3 Kinase p110α.

Package Size :

100 µg

Uses :

Western Blotting;Immunoprecipitation;Immunohistochemistry;ELISA

Storage :

Stable for 1 year at 2-8ºC from date of receipt.