TKS5 (SH3 #1) Antibody | EMD Millipore 09-403 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TKS5 (SH3 #1) Antibody

catalog :

09-403

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:200; loading ...; fig 2c	Donnelly S, Cabrera R, Mao S, Christin J, Wu B, Guo W, et al. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol. 2017;216:4331-4349 pubmed publisher
	Williams K, Cepeda M, Javed S, Searle K, Parkins K, Makela A, et al. Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis. Oncogene. 2019;38:3598-3615 pubmed publisher

product information

Catalog Number :

09-403

Subcategory :

Cell Structure

Product Name :

Anti-TKS5 (SH3 #1) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

O89032

Host Name :

Rabbit

Antigen :

TKS5 (SH3 #1)

Conjugate :

Purified

Product Description :

Anti-TKS5 (SH3 #1) Antibody

Cross Reactivity :

Human;Mouse

Background :

Tks5 (previously known as Fish), is a large scaffolding protein with one amino-terminal PX domain and five SH3 domains. It is cytoplasmic in normal fibroblasts. In Src-transformed cells, Tks5 localizes to podosomes. The coexpression of Tks5 and constitutively active Src in epithelial cancer cells resulted in the appearance of podosomes/invadopodia. Cells with reduced Tks5 expression are poorly invasive through matrigel. Tks5 is expressed and localized to podosomes/invadopodia in some invasive human cancer cell lines and tumor tissue, particularly breast cancers and melanomas. Thus, Tks5 appears to be required for podosome/invadopodia formation and for invasion of some cancer cells.

ALT Names :

Adaptor protein TKS5 ;Five SH3 domain-containing protein ;SH3 and PX domains 2A ;SH3 multiple domains 1;SH3 multiple domains protein 1;five SH3 domains

Immunogen :

Recombinant Protein, aa: 166-225. Homology: Human, Dog, Horse, Rat, Cow (100%, 60/60); Chicken (93%, 56/60)

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry;Immunoprecipitation

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.