Rac1b Antibody | EMD Millipore 09-271 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Rac1b Antibody

catalog :

09-271

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1a	Ungefroren H, Otterbein H, Fiedler C, Mihara K, Hollenberg M, Gieseler F, et al. RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5. Cancers (Basel). 2019;11: pubmed publisher

product information

Catalog Number :

09-271

Subcategory :

Cell Signaling

Product Name :

Anti-Rac1b Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P63000

Host Name :

Rabbit

Antigen :

Rac1b

Conjugate :

Affinity Purified

Product Description :

Anti-Rac1b Antibody

Cross Reactivity :

Human;Mouse

Background :

Rac is a member of the Rho family of small GTP-binding proteins. It plays roles in cytoskeletal actin organization as well as transformation along with its other Rho family members. Rac, Rho, and Cdc42 all work in concert with one another in the assembly of actin-based structures such as lamellipodia, stress fibers, and filopodia, respectively to control cell migration. Rac is activated downstream of cdc42, or independently by Ras signaling, and in turn Rac stimulates Rho. Effectors of the Rac pathway include NADPH Oxidase and the SAPK1/JNK family of kinases. The latter pathway is activated by the PAK kinases, which are direct targets of Rac. Rac1b is a highly active splice varient of Rac1. It differs in that it has an additional 19 amino acids. It has been found in various tumors such as breasts and colorectal.

Immunogen :

Synthetic peptide consisting of the internal region of Rac1b that is not in the other Rac1 isoforms.

Specificity :

Recognizes Rac1b specifically. Does not recognize other Rac1 isoforms.

Package Size :

100 μL

Uses :

Western Blotting;Immunohistochemistry (Paraffin);Immunofluorescence

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.