GATA3 Antibody | EMD Millipore 09-076 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GATA3 Antibody

catalog :

09-076

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Catalog Number :

09-076

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-GATA3 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P23771

Host Name :

Rabbit

Antigen :

GATA3

Conjugate :

Affinity Purified

Isotype :

IgG

Product Description :

Anti-GATA3 Antibody

Cross Reactivity :

Human;Rat

Background :

GATA3 is a transcription factor containing a zinc finger domain. GATA3 is primarily expressed in T cells, where it thought to participate in T-cell receptor gene activation through binding to enhancers. Analysis of conditional Gata3 knockout mice confirmed the critical role of GATA-3 in helper T cell differentiation and proliferation. Cells expressing GATA-3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. Binding of GATA-3 in the regulatory regions of the genes of these cytokines alters chromatin structure, increasing accessibility to other transcription factors. T cell receptor activation activates NFAT and other transcription factors that cooperate with GATA-3 in inducing Th2 cell differentiation. Blocking GATA-3 action has been suggested as a therapeutic strategy to treat asthma. GATA-3 has also been implicated in developmental processes such as the development of the inner ear.

ALT Names :

GATA binding protein 3 GATA-binding factor 3 HDR 2 Trans-acting T-cell-specific transcription factor GATA-3 MGC2346 MGC5199 MGC5445

Immunogen :

KLH conjugated synthetic peptide (VTADQPRWVSHHHPA(C) corresponding to a.a. 3-17 of human GATA3

Specificity :

Recognizes GATA3

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.