α-Insulin Receptor Antibody, β subunit | EMD Millipore 07-724 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

α-Insulin Receptor Antibody, β subunit

catalog :

07-724

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 1a	Hwang J, Kim A, Kim K, Il Park J, Oh H, Moon S, et al. TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression. Nat Commun. 2019;10:421 pubmed publisher
	Wang L, Scott I, Zhu L, Wu K, Han K, Chen Y, et al. GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis. Nat Commun. 2017;8:523 pubmed publisher

product information

Catalog Number :

07-724

Subcategory :

Cell Signaling

Product Name :

Anti-α-Insulin Receptor Antibody, β subunit

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P06213

Host Name :

Rabbit

Antigen :

α-Insulin Receptor

Conjugate :

Affinity Purified

Product Description :

Anti-α-Insulin Receptor Antibody, β subunit

Cross Reactivity :

Human;Mouse;Rat;Chimpanzee

Background :

The insulin receptor is a tyrosine kinase receptor that when bound to insulin, initiates multiple signal transduction pathways, including JNK, PI 3-kinase, Akt and PKC. Pharmacological intervention of these Insulin R-dependent pathways is of great interest for the treatment of insulin resistance, obesity and diabetes. The Insulin Receptor (IR) is synthesized as a single polypeptide, which is subsequently cleaved to generate an extracellular α-chain and a transmembrane and intracellular β-chain, tethered together by disulfide bonds. The β-chain has multiple tyrosine phosphorylation sites, including three autophosphorylation sites at its activation loop. The overall structure of the IR is highly homologous to the IGF-I Receptor, except in their c-termini, where the two proteins diverge somewhat. The IR signals primarily by phosphorylating the Insulin Receptor Substrate (IRS) family of proteins, which creates docking sites for SH2-domain containing proteins. Insulin signaling is highly dependent on the PI3 Kinase pathway and Akt, which appear to mediate the functions of insulin.

ALT Names :

CD220 antigen ;insulin receptor

Immunogen :

GST-fusion protein corresponding to the last 100 C-terminal amino acid residues of the human insulin receptor β chain

Specificity :

This antibody recognizes α-Insulin Receptor, β subunit.

Package Size :

100 μL

Uses :

Immunoprecipitation;Western Blotting

Storage :

Maintain refrigerated at 2-8°C for for 1 year from date of receipt.