phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody | EMD Millipore 07-722 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody

catalog :

07-722

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, chicken, bovine, zebrafish

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5a	DerangÃ¨re V, Fumet J, Boidot R, Bengrine L, Limagne E, Chevriaux A, et al. Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer?. Oncotarget. 2016;7:9309-21 pubmed publisher

product information

Catalog Number :

07-722

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P35968

Host Name :

Rabbit

Antigen :

phospho-VEGFR2/Flk-1/KDR (Tyr1054)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody

Cross Reactivity :

Human;Mouse;Rat;Primate;Bovine;Chicken;Horse;Zebrafish

Background :

The Flt gene family of receptor tyrosine kinases includes Flt-1, KDR/Flk-1, Flt-3, and Flt-4. They encode receptors for VEGF, characterized by seven Ig-loops within their extracellular domain and a split kinase domain within the cytoplasmic domain. VEGF is an important angiogenic factor of many solid tumors and is also involved in the differentiation of endothelial cells. Flt-1 (Fms-like tyrosine kinase, VEGF-R1) is expressed on endothelial cells and on the common precursors of endothelial and hematopoietic stem cells. KDR (Flk-1, VEGF-R2) is the principal receptor involved in VEGF signaling. KDR is expressed on endothelial cells and stimulates angiogenesis, but is also expressed on bone marrow cells, and is thought to play a role in driving the proliferation of most or all leukemic cells. Flt3 (also known as Flk-2) is a class III receptor tyrosine kinase that is closely related to c-Kit and c-Fms. It is expressed in primitive hematopoietic cells and its ligand exerts proliferative effects on these cells in co-operation with other cytokines.

ALT Names :

Kinase insert domain receptor;Protein-tyrosine kinase receptor Flk-1;kinase insert domain receptor (a type III receptor tyrosine kinase);vascular endothelial growth factor receptor 2

Immunogen :

Synthetic peptide encompassing

Specificity :

Recognizes VEGFR2/Flk-1/KDR when phosphorylated on Tyrosine 1054 (human).

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.