phospho-STAT1 (Ser727) Antibody | EMD Millipore 07-714 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-STAT1 (Ser727) Antibody

catalog :

07-714

quantity :

200 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs

application :

western blot

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 2. a, d	Gaston J, Cheradame L, Yvonnet V, Déas O, Poupon M, Judde J, et al. Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents. Oncotarget. 2016;7:77205-77224 pubmed publisher
	Nothstein A, Eiche E, Riemann M, Nick P, Winkel L, Göttlicher J, et al. Tracking Se Assimilation and Speciation through the Rice Plant - Nutrient Competition, Toxicity and Distribution. PLoS ONE. 2016;11:e0152081 pubmed publisher

product information

Catalog Number :

07-714

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-STAT1 (Ser727) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P42224

Host Name :

Rabbit

Antigen :

phospho-STAT1 (Ser727)

Conjugate :

Serum

Product Description :

Anti-phospho-STAT1 (Ser727) Antibody

Cross Reactivity :

Human;Mouse

Background :

STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. STAT 1, is activated by a number of different ligands, including IFNα, IFNγ, EGF, PDGF and IL6. Phosphorylation of tyrosine 701 is required for STAT 1 dissociation from IFNGR1, homodimerization, and nuclear translocation. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions.

Immunogen :

KLH-conjugated, synthetic peptide containing the sequence (PM[pS]PE), in which [pS] corresponds to phospho-serine at residue 727 of human STAT1. The immunizing sequence is identical in mouse, rat, canine and chimpanzee.

Specificity :

STAT1 phosphorylated on serine 727

Package Size :

200 µL

Uses :

Western Blotting

Storage :

2 years at -20°C from date of shipment