phospho-STAT3 (Ser727) Antibody | EMD Millipore 07-703 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-STAT3 (Ser727) Antibody

catalog :

07-703

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, dogs, chicken, bovine

application :

western blot

product information

Catalog Number :

07-703

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-STAT3 (Ser727) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P40763

Host Name :

Rabbit

Antigen :

phospho-STAT3 (Ser727)

Conjugate :

Affinity Purified

Isotype :

IgG

Product Description :

Anti-phospho-STAT3 (Ser727) Antibody

Cross Reactivity :

Mouse

Background :

STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. STAT3 has been shown to be activated by IFN-α but not IFN-β. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). Deletion of the STAT3 gene in knock out mice was lethal at the early embryonic stage.

Immunogen :

KLH-conjugated, synthetic peptide corresponding to amino acids 719-729 (C-SNTIDLPM[pS]PR) where pS corresponds to serine 727 of human STAT3 (Signal Transducer and Activator of Transcription 3)

Specificity :

phospho-STAT3 (Ser727)

Package Size :

100 µL

Uses :

Western Blotting

Storage :

1 year at -20°C from date of shipment