EZH2 Antibody | EMD Millipore 07-689 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

EZH2 Antibody

catalog :

07-689

quantity :

200 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry knockout validation

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; mouse; 1:1000; fig 1i	Lui J, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, et al. EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy. Nat Commun. 2016;7:13685 pubmed publisher
western blot; human; fig 1	Kawano S, Grassian A, Tsuda M, Knutson S, Warholic N, Kuznetsov G, et al. Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. PLoS ONE. 2016;11:e0158888 pubmed publisher
immunoprecipitation; human; loading ...; fig s7 immunocytochemistry; human; 1:2000; loading ...; fig s7	Dutta A, Le Magnen C, Mitrofanova A, Ouyang X, Califano A, Abate Shen C. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 2016;352:1576-80 pubmed publisher
western blot; human; 1:500; fig 3	Villasante A, Marturano Kruik A, Ambati S, Liu Z, Godier Furnemont A, Parsa H, et al. Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model. Theranostics. 2016;6:1119-30 pubmed publisher
	Schwarzer A, Emmrich S, Schmidt F, Beck D, Ng M, Reimer C, et al. The non-coding RNA landscape of human hematopoiesis and leukemia. Nat Commun. 2017;8:218 pubmed publisher

product information

Catalog Number :

07-689

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-EZH2 Antibody

Product Type :

Antibodies

Gene ID :

Q61188

Antigen :

EZH2

Conjugate :

Affinity Purified

Product Description :

Anti-EZH2 Antibody

Background :

Enhancer of zeste homologue 2 (EZH2), also known as Lysine N-methyltransferase 6 (KMT6), is a member of the polycomb group of proteins and is involved in cell cycle regulation. Polycomb protein group complexes are responsible for the regulation of hundreds of genes in mammals and insects. These proteins are responsible for the assembly and packaging of chromatin and for the induction of methylation on Histone H3. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27 trimethylation. The expression of this protein in human tumors is aggressive for hormone refractory prostate cancer. In breast cancer EZH2 expression was increased in malignant tumors and promoted anchorage independent and invasive growth in vitro. Defects in EZH2 are the cause of Weaver syndrome type 2 (WVS2).

ALT Names :

Histone-lysine N-methyltransferase EZH2;ENX-1;Enhancer of zeste homolog 2

Immunogen :

GST-tagged recombinant protein corresponding to the N-terminus of mouse EZH2.

Specificity :

This antibody recognizes the N-terminus of EZH2.

Package Size :

200 µL

Storage :

Stable for 1 year at 2-8°C from date of receipt