phospho-AMPKα (Thr172) Antibody | EMD Millipore 07-626 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-AMPKα (Thr172) Antibody

catalog :

07-626

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, chicken, bovine

application :

western blot

product information

Catalog Number :

07-626

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-AMPKα (Thr172) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q13131

Host Name :

Rabbit

Antigen :

phospho-AMPKα (Thr172)

Conjugate :

Affinity Purified

Isotype :

IgG

Product Description :

Anti-phospho-AMPKα (Thr172) Antibody

Cross Reactivity :

Human;Rat;Mouse;Horse;Chicken;Bovine

Background :

AMP-activated protein kinase (AMPK) is a metabolic and stress-sensing kinase that regulates homeostasis, and a key target for treating Type 2 diabetes and obesity. AMPK exists as a heterotrimeric complex comprised of catalytic alpha subunits (62 kDa) and non-catalytic beta and gamma subunits. The Alpha subunit has at least two isoforms (alpha 1 and alpha 2) that differ in their subcellular localization and AMP-dependence. AMPK is phosphorylated by upstream kinases, AMPK Kinase (AMPKK) and LKB1 which results in its activation. Active AMPK regulates metabolism by phosphorylating rate-limiting enzymes in metabolic pathways and controlling gene expression. Phosphorylation of threonine 172 in the activation loop of the alpha subunit is a key determinant of AMPK activity.

ALT Names :

5'-AMP-activated protein kinase, catalytic alpha-1 chain;AMP -activate kinase alpha 1 subunit;AMP-activated protein kinase, catalytic, alpha-1;AMPK alpha 1;AMPK alpha-1 chain;protein kinase, AMP-activated, alpha 1 catalytic subunit

Immunogen :

KLH-conjugated, synthetic peptide corresponding to amino acids surrounding phosphorylated Thr172 of human AMP-activated protein kinase alpha 2 (AMPKα2). The immunogenic site is conserved in AMPKα1, isoform 1 (Thr174), AMPKα1, isoform 2 (Thr189), and AMPKα2 (Thr172). Accession number NM_006251. The immunizing sequence is identical in rat.

Specificity :

This antibody recognizes AMPKα.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Maintain refrigerated at 2-8°C for 1 year from date of receipt.