p75NTR (Neurotrophin Receptor) Antibody | EMD Millipore 07-476 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p75NTR (Neurotrophin Receptor) Antibody

catalog :

07-476

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:500; fig 1	WILLIAMS K, KILLEBREW D, Clary G, Meeker R. Opposing Effects of NGF and proNGF on HIV Induced Macrophage Activation. J Neuroimmune Pharmacol. 2016;11:98-120 pubmed publisher
	Donnelly C, Gabreski N, Suh E, Chowdhury M, Pierchala B. Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons. J Cell Biol. 2018;217:3237-3253 pubmed publisher
	Antyborzec I, O Leary V, Dolly J, Ovsepian S. Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain. Neurotherapeutics. 2016;13:859-870 pubmed publisher
	Opazo M, Gianini A, Pancetti F, Azkcona G, Alarcon L, Lizana R, et al. Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring. Endocrinology. 2008;149:5097-106 pubmed publisher

product information

Catalog Number :

07-476

Subcategory :

Neuroscience

Product Name :

Anti-p75NTR (Neurotrophin Receptor) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q53EW1

Host Name :

Rabbit

Antigen :

p75NTR (Neurotrophin Receptor)

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-p75NTR (Neurotrophin Receptor) Antibody

Cross Reactivity :

Human;Rat;Mouse

Background :

The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. The neurotrophins are comprised of four proteins, all of which bind to the LNGFR: Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4). Nerve growth factor, the prototypical growth factor, is a protein secreted by a neuron's target. NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the cell body. This movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons.

ALT Names :

CD271 antigen;Low affinity neurotrophin receptor p75NTR;Low-affinity nerve growth factor receptor;NGF receptor;low affinity nerve growth factor receptor;nerve growth factor receptor;nerve growth factor receptor (TNFR superfamily, member 16);p75 ICD

Immunogen :

GST fusion protein corresponding to the intracellular domain (residues 274-425) of rat p75 neurotrophin receptor.

Specificity :

Recognizes p75 neurotrophin receptor, MW ~75 kDa.

Package Size :

100 μg

Uses :

Immunohistochemistry;Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.