This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
trimethyl-Histone H3 (Lys4) Antibody
catalog :
07-473
quantity :
100 μL
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
Tetrahymena thermophila, fission yeast, human, mouse, fruit fly , Xenopus laevis
application :
western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, ChIP-Seq
citations: 108
Published Application/Species/Sample/DilutionReference
  • chromatin immunoprecipitation; mouse; loading ...; fig 3i
Carpenter M, Hu Q, Bond A, Lombroso S, Czarnecki K, Lim C, et al. Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes. Nat Commun. 2020;11:504 pubmed publisher
  • chromatin immunoprecipitation; human; 1:100; loading ...; fig 6h
Liu Z, Wu C, Pan Y, Liu H, Wang X, Yang Y, et al. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Sci Adv. 2019;5:eaav0163 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 1e
Nishioka K, Miyazaki H, Soejima H. Unbiased shRNA screening, using a combination of FACS and high-throughput sequencing, enables identification of novel modifiers of Polycomb silencing. Sci Rep. 2018;8:12128 pubmed publisher
  • chromatin immunoprecipitation; human; 1:100; loading ...; fig 1h
Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s8a
Hervás Corpión I, Guiretti D, Alcaraz Iborra M, Olivares R, Campos Caro A, Barco A, et al. Early alteration of epigenetic-related transcription in Huntington's disease mouse models. Sci Rep. 2018;8:9925 pubmed publisher
  • ChIP-Seq; mouse; loading ...; fig 6p
Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, et al. Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Dev Cell. 2018;45:753-768.e8 pubmed publisher
  • ChIP-Seq; human; fig 3a
Liu X, Wu H, Krzisch M, Wu X, Graef J, Muffat J, et al. Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell. 2018;172:979-992.e6 pubmed publisher
  • western blot; human; loading ...; fig 1a
Deng H, Zeng J, Zhang T, Gong L, Zhang H, Cheung E, et al. Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma. Mol Cancer Res. 2018;16:623-633 pubmed publisher
  • ChIP-Seq; mouse; loading ...; fig s5a
Gao X, Lee H, Li W, Platt R, Barrasa M, Ma Q, et al. Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. Proc Natl Acad Sci U S A. 2017;114:10107-10112 pubmed publisher
  • chromatin immunoprecipitation; human; fig 4e
Lu F, Wiedmer A, Martin K, Wickramasinghe P, Kossenkov A, Lieberman P. Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus. J Virol. 2017;91: pubmed publisher
  • ChIP-Seq; human; loading ...; fig s7b
  • ChIP-Seq; mouse; fig s7b
Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169:243-257.e25 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 4c
Luo D, de Morrée A, Boutet S, Quach N, Natu V, Rustagi A, et al. Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c. Proc Natl Acad Sci U S A. 2017;114:E3071-E3080 pubmed publisher
  • ChIP-Seq; mouse; fig 2d
Kazakevych J, Sayols S, Messner B, Krienke C, Soshnikova N. Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells. Nucleic Acids Res. 2017;45:5770-5784 pubmed publisher
  • western blot; mouse; fig 4i
Guitart A, Panagopoulou T, Villacreces A, Vukovic M, Sepúlveda C, Allen L, et al. Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. J Exp Med. 2017;214:719-735 pubmed publisher
  • chromatin immunoprecipitation; mouse; 1:100; loading ...; fig 4a
Fu N, Rios A, Pal B, Law C, Jamieson P, Liu R, et al. Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive. Nat Cell Biol. 2017;19:164-176 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 6b
Lin Y, Lin Y, Huang M, Kuo P, Wu C, Lee M, et al. Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification. Mol Immunol. 2017;83:82-91 pubmed publisher
  • western blot; Tetrahymena thermophila; loading ...; fig 2e
Arthur L, Chung J, Jankirama P, Keefer K, Kolotilin I, Pavlovic Djuranovic S, et al. Rapid generation of hypomorphic mutations. Nat Commun. 2017;8:14112 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 7f
Bao K, Carr T, Wu J, Barclay W, Jin J, Ciofani M, et al. BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity. J Immunol. 2016;197:4371-4381 pubmed
  • chromatin immunoprecipitation; mouse; loading ...
Tahmasebi S, Jafarnejad S, Tam I, Gonatopoulos Pournatzis T, Matta Camacho E, Tsukumo Y, et al. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proc Natl Acad Sci U S A. 2016;113:12360-12367 pubmed
  • chromatin immunoprecipitation; mouse; 1:1000; loading ...; fig 6a
Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto A, Yang Y, Ntziachristos P, et al. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nat Cell Biol. 2016;18:1127-1138 pubmed publisher
  • ChIP-Seq; mouse; fig 2s1
Illingworth R, Hölzenspies J, Roske F, Bickmore W, Brickman J. Polycomb enables primitive endoderm lineage priming in embryonic stem cells. elife. 2016;5: pubmed publisher
  • chromatin immunoprecipitation; human; fig 5
Wu H, Li S, Hu J, Yu X, Xu H, Chen Z, et al. Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells. J Exp Clin Cancer Res. 2016;35:145 pubmed publisher
  • ChIP-Seq; human; loading ...; fig 7a
Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, et al. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Mol Cell. 2016;63:470-84 pubmed publisher
  • western blot; Xenopus laevis; fig 1
  • immunoprecipitation; mouse; fig 6
  • western blot; mouse; fig 6
Powers N, Parvanov E, Baker C, Walker M, Petkov P, Paigen K. The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo. PLoS Genet. 2016;12:e1006146 pubmed publisher
  • western blot; mouse; fig 1s2
Deaton A, Gómez Rodríguez M, Mieczkowski J, Tolstorukov M, Kundu S, Sadreyev R, et al. Enhancer regions show high histone H3.3 turnover that changes during differentiation. elife. 2016;5: pubmed publisher
  • western blot; mouse; fig s10
Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher
  • chromatin immunoprecipitation; human; fig 5
Kim J, Yu J, Abdulkadir S, Chakravarti D. KAT8 Regulates Androgen Signaling in Prostate Cancer Cells. Mol Endocrinol. 2016;30:925-36 pubmed publisher
  • western blot; human; loading ...; fig 1b
Fang D, Gan H, Lee J, Han J, Wang Z, Riester S, et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 2016;352:1344-8 pubmed publisher
  • chromatin immunoprecipitation; fission yeast; fig 1e
Materne P, Vazquez E, Sanchez M, Yague Sanz C, Anandhakumar J, Migeot V, et al. Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus. elife. 2016;5: pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 4
Cozzolino A, Noce V, Battistelli C, Marchetti A, Grassi G, Cicchini C, et al. Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes. Stem Cells Int. 2016;2016:5481493 pubmed publisher
  • chromatin immunoprecipitation; human; fig 1
Dheekollu J, Wiedmer A, Sentana Lledo D, Cassel J, Messick T, Lieberman P. HCF1 and OCT2 Cooperate with EBNA1 To Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr Virus. J Virol. 2016;90:5353-5367 pubmed publisher
  • western blot; fruit fly ; 1:2000; fig 7
Akan I, Love D, Harwood K, Bond M, Hanover J. Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O-GlcNAcylation. J Biol Chem. 2016;291:9906-19 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 1
Hwang S, Jang S, Kim M, Kim L, Kim B, Kim H, et al. YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity. Nat Commun. 2016;7:10789 pubmed publisher
  • chromatin immunoprecipitation; human; fig 5
Stein C, Nötzold R, Riedl S, Bouchard C, Bauer U. The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression. PLoS ONE. 2016;11:e0148892 pubmed publisher
  • ChIP-Seq; mouse; fig 5
Walter M, Teissandier A, Pérez Palacios R, Bourc his D. An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells. elife. 2016;5: pubmed publisher
  • ChIP-Seq; human; fig 1
Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, et al. IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis. Sci Rep. 2016;6:19174 pubmed publisher
  • ChIP-Seq; human; fig 3
Lu F, Chen H, Kossenkov A, DeWispeleare K, Won K, Lieberman P. EBNA2 Drives Formation of New Chromosome Binding Sites and Target Genes for B-Cell Master Regulatory Transcription Factors RBP-jκ and EBF1. PLoS Pathog. 2016;12:e1005339 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 7a
Shields B, Jackson J, Metcalf D, Shi W, Huang Q, Garnham A, et al. Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a. Genes Dev. 2016;30:78-91 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 5e
Liu G, Zhao G, Chen X, Hao D, Zhao X, Lv X, et al. The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster. Nucleic Acids Res. 2016;44:2613-27 pubmed publisher
Dunican D, Mjoseng H, Duthie L, Flyamer I, Bickmore W, Meehan R. Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells. BMC Biol. 2020;18:25 pubmed publisher
Majumder P, Lee J, Rahmberg A, Kumar G, Mi T, Scharer C, et al. A super enhancer controls expression and chromatin architecture within the MHC class II locus. J Exp Med. 2020;217: pubmed publisher
Zhang H, Khoa L, Mao F, Xu H, Zhou B, Han Y, et al. MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State. Cell Rep. 2019;29:2659-2671.e6 pubmed publisher
Ricci W, Lu Z, Ji L, Marand A, Ethridge C, Murphy N, et al. Widespread long-range cis-regulatory elements in the maize genome. Nat Plants. 2019;5:1237-1249 pubmed publisher
Wu R, Young I, Chen Y, Chuang S, Toubaji A, Wu M. Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer. Nat Commun. 2019;10:4332 pubmed publisher
Zoeller E, PEDRO B, Konen J, Dwivedi B, Rupji M, Sundararaman N, et al. Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes. J Cell Sci. 2019;132: pubmed publisher
Li L, Ruan X, Wen C, Chen P, Liu W, Zhu L, et al. The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Cell Rep. 2019;28:698-711.e5 pubmed publisher
Fiorucci A, Bourbousse C, Concia L, Rougée M, Deton Cabanillas A, Zabulon G, et al. Arabidopsis S2Lb links AtCOMPASS-like and SDG2 activity in H3K4me3 independently from histone H2B monoubiquitination. Genome Biol. 2019;20:100 pubmed publisher
de Almeida B, Noronha R, da Costa M, Nagamachi C, Pieczarka J. Meiosis in the scorpion Tityus silvestris: new insights into achiasmatic chromosomes. Biol Open. 2019;8: pubmed publisher
Hu X, Liu Z, Chen X, Schulz V, Kumar A, Hartman A, et al. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nat Commun. 2019;10:1695 pubmed publisher
Ebrahimi A, Sevinç K, Gürhan Sevinç G, Cribbs A, Philpott M, Uyulur F, et al. Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming. Nat Chem Biol. 2019;15:519-528 pubmed publisher
Ogawa Y, Shiraki T, Asano Y, Muto A, Kawakami K, Suzuki Y, et al. Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Cui S, Li L, Yu R, Downes M, Evans R, Hulin J, et al. β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin. Development. 2019;146: pubmed publisher
Jang Y, Broun A, Wang C, Park Y, Zhuang L, Lee J, et al. H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development. Nucleic Acids Res. 2019;47:607-620 pubmed publisher
Lavado A, Park J, Pare J, Finkelstein D, Pan H, Xu B, et al. The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Dev Cell. 2018;47:576-591.e8 pubmed publisher
Moon S, Im S, Kim N, Youn H, Park U, Kim J, et al. Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. Cell Death Dis. 2018;9:1118 pubmed publisher
Greenfield R, Tabib A, Keshet I, Moss J, Sabag O, Goren A, et al. Role of transcription complexes in the formation of the basal methylation pattern in early development. Proc Natl Acad Sci U S A. 2018;115:10387-10391 pubmed publisher
Nishiguchi M, Spencer C, Leung D, Leung T. Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration. Cell Rep. 2018;24:3383-3392.e5 pubmed publisher
Yao R, Wang Y, Han D, Ma Y, Ma M, Zhao Y, et al. Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration. Oncol Rep. 2018;40:3069-3077 pubmed publisher
Brick K, Thibault Sennett S, Smagulova F, Lam K, Pu Y, Pratto F, et al. Extensive sex differences at the initiation of genetic recombination. Nature. 2018;561:338-342 pubmed publisher
Ruzycki P, Zhang X, Chen S. CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites. Epigenetics Chromatin. 2018;11:42 pubmed publisher
Mishra S, Van Rechem C, Pal S, Clarke T, Chakraborty D, Mahan S, et al. Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell. 2018;174:803-817.e16 pubmed publisher
Gu T, Lin X, Cullen S, Luo M, Jeong M, Estecio M, et al. DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells. Genome Biol. 2018;19:88 pubmed publisher
Slaughter M, Shanle E, McFadden A, Hollis E, Suttle L, Strahl B, et al. PBRM1 bromodomains variably influence nucleosome interactions and cellular function. J Biol Chem. 2018;293:13592-13603 pubmed publisher
Kim K, Tanaka Y, Su J, Cakir B, Xiang Y, Patterson B, et al. Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a. Nat Commun. 2018;9:2583 pubmed publisher
Tanaka S, Jiang Y, Martinez G, Tanaka K, Yan X, Kurosaki T, et al. Trim33 mediates the proinflammatory function of Th17 cells. J Exp Med. 2018;215:1853-1868 pubmed publisher
Jangid R, Kelkar A, Muley V, Galande S. Bidirectional promoters exhibit characteristic chromatin modification signature associated with transcription elongation in both sense and antisense directions. BMC Genomics. 2018;19:313 pubmed publisher
Pradhan R, Ranade D, Sengupta K. Emerin modulates spatial organization of chromosome territories in cells on softer matrices. Nucleic Acids Res. 2018;46:5561-5586 pubmed publisher
Thibault Sennett S, Yu Q, Smagulova F, Cloutier J, Brick K, Camerini Otero R, et al. Interrogating the Functions of PRDM9 Domains in Meiosis. Genetics. 2018;209:475-487 pubmed publisher
Anan K, Hino S, Shimizu N, Sakamoto A, Nagaoka K, Takase R, et al. LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation. Nucleic Acids Res. 2018;46:5441-5454 pubmed publisher
Hall A, Battenhouse A, Shivram H, Morris A, Cowperthwaite M, Shpak M, et al. Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells. Cancer Res. 2018;78:2463-2474 pubmed publisher
Poli V, Fagnocchi L, Fasciani A, Cherubini A, Mazzoleni S, Ferrillo S, et al. MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state. Nat Commun. 2018;9:1024 pubmed publisher
Feld C, Sahu P, Frech M, Finkernagel F, Nist A, Stiewe T, et al. Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1. Nucleic Acids Res. 2018;46:3412-3428 pubmed publisher
Henriques T, Scruggs B, Inouye M, Muse G, Williams L, Burkholder A, et al. Widespread transcriptional pausing and elongation control at enhancers. Genes Dev. 2018;32:26-41 pubmed publisher
Zhao D, Hamilton J, Vaillancourt B, Zhang W, Eizenga G, Cui Y, et al. The unique epigenetic features of Pack-MULEs and their impact on chromosomal base composition and expression spectrum. Nucleic Acids Res. 2018;46:2380-2397 pubmed publisher
Bogeas A, Morvan Dubois G, El Habr E, Lejeune F, Defrance M, Narayanan A, et al. Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness. Acta Neuropathol. 2018;135:267-283 pubmed publisher
Song S, Jeon M, Nam J, Kang J, Lee Y, Kang J, et al. Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer. Oncogene. 2018;37:993-1004 pubmed publisher
Lu L, Chen J, Robb S, Okumoto Y, Stajich J, Wessler S. Tracking the genome-wide outcomes of a transposable element burst over decades of amplification. Proc Natl Acad Sci U S A. 2017;114:E10550-E10559 pubmed publisher
Nguyen H, Dong J, Panchakshari R, Kumar V, Alt F, Bories J. Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination. Proc Natl Acad Sci U S A. 2017;114:E10560-E10567 pubmed publisher
Kiese K, Jablonski J, Hackenbracht J, Wrosch J, Groemer T, Kornhuber J, et al. Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons. Acta Neuropathol Commun. 2017;5:79 pubmed publisher
Stroud H, Su S, Hrvatin S, Greben A, Renthal W, Boxer L, et al. Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States. Cell. 2017;171:1151-1164.e16 pubmed publisher
Cheng J, Park D, Berrios C, White E, Arora R, Yoon R, et al. Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. PLoS Pathog. 2017;13:e1006668 pubmed publisher
Yao X, Tan J, Lim K, Koh J, Ooi W, Li Z, et al. VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2017;7:1284-1305 pubmed publisher
Lyu Y, Nakano K, Davis R, Tepper C, Campbell M, Izumiya Y. ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation. J Virol. 2017;91: pubmed publisher
Korb E, Herre M, Zucker Scharff I, Gresack J, Allis C, Darnell R. Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Cell. 2017;170:1209-1223.e20 pubmed publisher
Xu J, Xu X, Wang B, Ma Y, Zhang L, Xu H, et al. Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response. Proc Natl Acad Sci U S A. 2017;114:8620-8625 pubmed publisher
Maina P, Shao P, Jia X, Liu Q, Umesalma S, Marin M, et al. Histone demethylase PHF8 regulates hypoxia signaling through HIF1? and H3K4me3. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1002-1012 pubmed publisher
Deakyne J, Malecka K, Messick T, Lieberman P. Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance. J Virol. 2017;91: pubmed publisher
Semba Y, Harada A, Maehara K, Oki S, Meno C, Ueda J, et al. Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells. Nucleic Acids Res. 2017;45:8758-8772 pubmed publisher
Li Y, Jiao J. Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin. J Cell Biol. 2017;216:1975-1992 pubmed publisher
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Lee Y, Park D, Iyer V. The ATP-dependent chromatin remodeler Chd1 is recruited by transcription elongation factors and maintains H3K4me3/H3K36me3 domains at actively transcribed and spliced genes. Nucleic Acids Res. 2017;45:7180-7190 pubmed publisher
Lai B, Lee J, Jang Y, Wang L, Peng W, Ge K. MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis. Nucleic Acids Res. 2017;45:6388-6403 pubmed publisher
Teveroni E, Pellegrino M, Sacconi S, Calandra P, Cascino I, Farioli Vecchioli S, et al. Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity. J Clin Invest. 2017;127:1531-1545 pubmed publisher
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Simon C, Downes D, Gosden M, Telenius J, Higgs D, Hughes J, et al. Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo. Development. 2017;144:1249-1260 pubmed publisher
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Yu X, Zhang Y, Li T, Ma Z, Jia H, Chen Q, et al. Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD. Nat Commun. 2017;8:14016 pubmed publisher
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Liau B, Sievers C, Donohue L, Gillespie S, Flavahan W, Miller T, et al. Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Cell Stem Cell. 2017;20:233-246.e7 pubmed publisher
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Saintamand A, Vincent Fabert C, Garot A, Rouaud P, Oruc Z, Magnone V, et al. Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region. Nat Commun. 2016;7:10730 pubmed publisher
Mursalimov S, Permyakova N, Deineko E, Houben A, Demidov D. Cytomixis doesn't induce obvious changes in chromatin modifications and programmed cell death in tobacco male meiocytes. Front Plant Sci. 2015;6:846 pubmed publisher
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Beshiri M, Holmes K, Richter W, HESS S, Islam A, Yan Q, et al. Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. Proc Natl Acad Sci U S A. 2012;109:18499-504 pubmed publisher
product information
Catalog Number :
07-473
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-trimethyl-Histone H3 (Lys4) Antibody
Product Type :
Antibodies
Clonality :
Polyclonal Antibody
Gene ID :
Q16695
Host Name :
Rabbit
Antigen :
trimethyl-Histone H3 (Lys4)
Conjugate :
Affinity Purified
Product Description :
Anti-trimethyl-Histone H3 (Lys4) Antibody
Cross Reactivity :
Human;Vertebrates
Background :
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
ALT Names :
H3K4me3;Histone H3 (tri methyl K4);H3 histone family, member T;histone 3, H3;histone cluster 3, H3
Immunogen :
Synthetic peptide corresponding to residues surrounding and including trimethlyated Lys 4 of Histone H3.
Specificity :
This antibody only detects Histone H3 when trimethylated on Lysine 4.
Package Size :
100 μL
Uses :
Dot Blot;Western Blotting;ChIP-seq;Chromatin Immunoprecipitation (ChIP)
Storage :
Stable for 1 year at 2-8ºC from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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