CoREST Antibody | EMD Millipore 07-455 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CoREST Antibody

catalog :

07-455

quantity :

200 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, RNA immunoprecipitation

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 1e	Hu X, Xiang D, Xie Y, Tao L, Zhang Y, Jin Y, et al. LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression. Oncogene. 2019;38:7017-7034 pubmed publisher
western blot; human; loading ...; fig 3a	Lambert M, Terrone S, Giraud G, Benoit Pilven C, Cluet D, Combaret V, et al. The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation. Nucleic Acids Res. 2018;46:7686-7700 pubmed publisher
RNA immunoprecipitation; human; fig 7b	Qi F, Liu X, Wu H, Yu X, Wei C, Huang X, et al. Long noncoding AGAP2-AS1 is activated by SP1 and promotes cell proliferation and invasion in gastric cancer. J Hematol Oncol. 2017;10:48 pubmed publisher
western blot; human; loading ...; fig 4a	Ishikawa Y, Gamo K, Yabuki M, Takagi S, Toyoshima K, Nakayama K, et al. A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells. Mol Cancer Ther. 2017;16:273-284 pubmed publisher
immunoprecipitation; mouse; fig 4d	Hagelkruys A, Mattes K, Moos V, Rennmayr M, Ringbauer M, Sawicka A, et al. Essential Nonredundant Function of the Catalytic Activity of Histone Deacetylase 2 in Mouse Development. Mol Cell Biol. 2016;36:462-74 pubmed publisher
	Wang S, Ko S, Jo S, Jo H, Han J, Kim Y, et al. Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2. Exp Neurobiol. 2019;28:537-546 pubmed publisher
	Guo Y, Fu X, Huo B, Wang Y, Sun J, Meng L, et al. GATA2 regulates GATA1 expression through LSD1-mediated histone modification. Am J Transl Res. 2016;8:2265-74 pubmed

product information

Catalog Number :

07-455

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-CoREST Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q9UKL0

Host Name :

Rabbit

Antigen :

CoREST

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-CoREST Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

The CoREST gene encodes a functional corepressor required for regulation of neural specific gene expression. REST (RE1 silencing transcription factor 1) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long term gene silencing using a distinct functional complex. Silencing of neuronal specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST response elements.

Immunogen :

GST fusion protein corresponding to residues 109-293 of human CoREST.

Specificity :

Recognizes CoREST.

Package Size :

200 μg

Uses :

Immunocytochemistry;Immunohistochemistry;Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt