| Published Application/Species/Sample/Dilution | Reference |
|---|
- chromatin immunoprecipitation; mouse; loading ...; fig 3j
| Carpenter M, Hu Q, Bond A, Lombroso S, Czarnecki K, Lim C, et al. Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes. Nat Commun. 2020;11:504 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig s5a
- western blot; human; loading ...; fig s5d
| Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, et al. Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. Nat Commun. 2019;10:2229 pubmed publisher |
- ChIP-Seq; mouse; loading ...; fig 3j
| Kelly M, So J, Rogers A, Gregory G, Li J, Zethoven M, et al. Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis. Nat Commun. 2019;10:1347 pubmed publisher |
- western blot; human; loading ...; fig s6d
| Wei X, Guo J, Li Q, Jia Q, Jing Q, Li Y, et al. Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells. Sci Adv. 2019;5:eaau7887 pubmed publisher |
- chromatin immunoprecipitation; human; 1:100; loading ...; fig 6g
| Liu Z, Wu C, Pan Y, Liu H, Wang X, Yang Y, et al. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Sci Adv. 2019;5:eaav0163 pubmed publisher |
- chromatin immunoprecipitation; mouse; loading ...; fig s9a
| Nicetto D, Donahue G, Jain T, Peng T, Sidoli S, Sheng L, et al. H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification. Science. 2019;363:294-297 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig s1g
| Zhu Y, Wang G, Cingoz O, Goff S. NP220 mediates silencing of unintegrated retroviral DNA. Nature. 2018;564:278-282 pubmed publisher |
- immunocytochemistry; mouse; 1:500; loading ...; fig s10a
| Inoue A, Chen Z, Yin Q, Zhang Y. Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells. Genes Dev. 2018;32:1525-1536 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 2b
- western blot; mouse; loading ...; fig 2a
| Ferreira M, Verbinnen I, Fardilha M, Van Eynde A, Bollen M. The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2. J Biol Chem. 2018;293:18031-18039 pubmed publisher |
- ChIP-Seq; human; loading ...; fig 5b
| Stewart E, McEvoy J, Wang H, Chen X, Honnell V, Ocarz M, et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018;34:411-426.e19 pubmed publisher |
- chromatin immunoprecipitation; mouse; loading ...; fig 1e
| Nishioka K, Miyazaki H, Soejima H. Unbiased shRNA screening, using a combination of FACS and high-throughput sequencing, enables identification of novel modifiers of Polycomb silencing. Sci Rep. 2018;8:12128 pubmed publisher |
- western blot; mouse; loading ...; fig 1c
| Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, et al. Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation. J Clin Invest. 2018;128:3872-3886 pubmed publisher |
- chromatin immunoprecipitation; human; 1:100; loading ...; fig 1h
| Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Deng H, Zeng J, Zhang T, Gong L, Zhang H, Cheung E, et al. Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma. Mol Cancer Res. 2018;16:623-633 pubmed publisher |
- western blot; American tobacco; fig s1c
- chromatin immunoprecipitation; thale cress; loading ...; fig s6e
- western blot; thale cress; loading ...; fig s6a
| Jiang D, Berger F. DNA replication-coupled histone modification maintains Polycomb gene silencing in plants. Science. 2017;357:1146-1149 pubmed publisher |
- western blot; human; fig 4d
| Wang J, Cheng P, Pavlyukov M, Yu H, Zhang Z, Kim S, et al. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2017;127:3075-3089 pubmed publisher |
- chromatin immunoprecipitation; fruit fly ; loading ...; tbl s2
- immunohistochemistry; fruit fly ; 1:100; loading ...; tbl s2
| Zenk F, Loeser E, Schiavo R, Kilpert F, Bogdanović O, Iovino N. Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition. Science. 2017;357:212-216 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 6f
| Huo Y, Li Q, Wang X, Jiao X, Zheng J, Li Z, et al. MALAT1 predicts poor survival in osteosarcoma patients and promotes cell metastasis through associating with EZH2. Oncotarget. 2017;8:46993-47006 pubmed publisher |
- ChIP-Seq; human; loading ...; fig s7b
- ChIP-Seq; mouse; fig s7b
| Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169:243-257.e25 pubmed publisher |
- ChIP-Seq; mouse; loading ...; fig 3a
| Endoh M, Endo T, Shinga J, Hayashi K, Farcas A, Ma K, et al. PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes. elife. 2017;6: pubmed publisher |
- western blot; human; loading ...; fig 2b
| Douet J, Corujo D, Malinverni R, Renauld J, Sansoni V, Posavec Marjanović M, et al. MacroH2A histone variants maintain nuclear organization and heterochromatin architecture. J Cell Sci. 2017;130:1570-1582 pubmed publisher |
- chromatin immunoprecipitation; mouse; loading ...; tbl s3
| Lau M, Schwartz M, Kundu S, Savol A, Wang P, Marr S, et al. Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science. 2017;355:1081-1084 pubmed publisher |
- western blot; roundworm ; 1:2500; fig s5a
| Amendola P, Zaghet N, Ramalho J, Vilstrup Johansen J, Boxem M, Salcini A. JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity. PLoS Genet. 2017;13:e1006632 pubmed publisher |
- western blot; mouse; fig 4i
| Guitart A, Panagopoulou T, Villacreces A, Vukovic M, Sepúlveda C, Allen L, et al. Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. J Exp Med. 2017;214:719-735 pubmed publisher |
- chromatin immunoprecipitation; mouse; 1:100; loading ...; fig 4a
| Fu N, Rios A, Pal B, Law C, Jamieson P, Liu R, et al. Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive. Nat Cell Biol. 2017;19:164-176 pubmed publisher |
- western blot; mouse; fig 4c
| Wu N, Jia D, Bates B, Basom R, Eberhart C, MacPherson D. A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence. J Clin Invest. 2017;127:888-898 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 6b
| Lin Y, Lin Y, Huang M, Kuo P, Wu C, Lee M, et al. Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification. Mol Immunol. 2017;83:82-91 pubmed publisher |
- other; human; loading ...; fig 6-s4
| Skene P, Henikoff S. An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites. elife. 2017;6: pubmed publisher |
- ChIP-Seq; mouse; loading ...; fig 5a
| Wu H, Gordon J, Whitfield T, Tai P, Van Wijnen A, Stein J, et al. Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis. Biochim Biophys Acta Gene Regul Mech. 2017;1860:438-449 pubmed publisher |
- immunohistochemistry; mouse; 1:100; loading ...; fig 4c
| Benevento M, Oomen C, Horner A, Amiri H, Jacobs T, Pauwels C, et al. Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation. Sci Rep. 2017;7:40284 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:600; fig s2c
| Hennika T, Hu G, Olaciregui N, Barton K, Ehteda A, Chitranjan A, et al. Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models. PLoS ONE. 2017;12:e0169485 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Jin X, Wu N, Dai J, Li Q, Xiao X. TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment. Cancer Med. 2017;6:424-438 pubmed publisher |
- ChIP-Seq; human; loading ...; fig s4a
| Ang Y, Rivas R, Ribeiro A, Srivas R, Rivera J, Stone N, et al. Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis. Cell. 2016;167:1734-1749.e22 pubmed publisher |
- western blot; human; loading ...; fig s5a
| Ma W, Tummers B, van Esch E, Goedemans R, Melief C, Meyers C, et al. Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFN?- and TNF?-Mediated Antiproliferative Effects and Necroptosis. Front Immunol. 2016;7:496 pubmed |
- chromatin immunoprecipitation; mouse; loading ...; fig 4b
- immunohistochemistry; mouse; 1:1000; fig 4f
| Lui J, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, et al. EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy. Nat Commun. 2016;7:13685 pubmed publisher |
- chromatin immunoprecipitation; mouse; loading ...; fig 2i
| Lepage D, Bélanger É, Jones C, Tremblay S, Allaire J, Bruneau J, et al. Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury. Sci Rep. 2016;6:36776 pubmed publisher |
- chromatin immunoprecipitation; mouse; loading ...; fig 6b
- immunohistochemistry; mouse; 1:200; loading ...; fig s3f
| Fukuda A, Mitani A, Miyashita T, Sado T, Umezawa A, Akutsu H. Maintenance of Xist Imprinting Depends on Chromatin Condensation State and Rnf12 Dosage in Mice. PLoS Genet. 2016;12:e1006375 pubmed publisher |
- ChIP-Seq; mouse; fig 2
- immunocytochemistry; mouse; 2000 ng/ml; fig 3
- western blot; mouse; 2000 ng/ml; fig 4
| Illingworth R, Hölzenspies J, Roske F, Bickmore W, Brickman J. Polycomb enables primitive endoderm lineage priming in embryonic stem cells. elife. 2016;5: pubmed publisher |
- ChIP-Seq; mouse; loading ...; fig 1c
| Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, et al. Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia. Genes Dev. 2016;30:1971-90 pubmed publisher |
- ChIP-Seq; fruit fly ; 1:1000; fig 3a
| Loubiere V, Delest A, Thomas A, Bonev B, Schuettengruber B, Sati S, et al. Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development. Nat Genet. 2016;48:1436-1442 pubmed publisher |
- chromatin immunoprecipitation; human; fig s9
- western blot; human; fig 2
| García Carpizo V, Sarmentero J, Han B, Grana O, Ruiz Llorente S, Pisano D, et al. NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation. Sci Rep. 2016;6:32952 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 3d
| Krook M, Hawkins A, Patel R, Lucas D, Van Noord R, Chugh R, et al. A bivalent promoter contributes to stress-induced plasticity of CXCR4 in Ewing sarcoma. Oncotarget. 2016;7:61775-61788 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 10e
- western blot; human; loading ...; fig 10c
| Achuthan A, Cook A, Lee M, Saleh R, Khiew H, Chang M, et al. Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. J Clin Invest. 2016;126:3453-66 pubmed publisher |
- ChIP-Seq; human; loading ...; fig 7a
| Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, et al. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Mol Cell. 2016;63:470-84 pubmed publisher |
| Zhang X, Wu J, Wang J, Shen T, Li H, Lu J, et al. Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells. Genome Biol. 2016;17:162 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 3a
- chromatin immunoprecipitation; mouse; loading ...; fig 3a
- western blot; mouse; loading ...; fig 3c
| Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher |
- chromatin immunoprecipitation; mouse; 1:300; fig 6
| Perdigoto C, Dauber K, Bar C, Tsai P, Valdes V, Cohen I, et al. Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS Genet. 2016;12:e1006151 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 7a
- western blot; mouse; fig 1c
| Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, et al. The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition. J Exp Med. 2016;213:1459-77 pubmed publisher |
- chromatin immunoprecipitation; thale cress; fig 6
| Shi B, Zhang C, Tian C, Wang J, Wang Q, Xu T, et al. Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis. PLoS Genet. 2016;12:e1006168 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 3b
| Itahana Y, Zhang J, Göke J, Vardy L, Han R, Iwamoto K, et al. Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells. Sci Rep. 2016;6:28112 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 4c
| Dutta A, Le Magnen C, Mitrofanova A, Ouyang X, Califano A, Abate Shen C. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 2016;352:1576-80 pubmed publisher |
- ChIP-Seq; mouse; loading ...; fig 4
| Omata Y, Nakamura S, Koyama T, Yasui T, Hirose J, Izawa N, et al. Identification of Nedd9 as a TGF-?-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis. PLoS ONE. 2016;11:e0157992 pubmed publisher |
- western blot; mouse; fig s10
| Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher |
| Woolnough J, Atwood B, Liu Z, Zhao R, Giles K. The Regulation of rRNA Gene Transcription during Directed Differentiation of Human Embryonic Stem Cells. PLoS ONE. 2016;11:e0157276 pubmed publisher |
- chromatin immunoprecipitation; thale cress; fig 5
| Li Z, Li B, Liu J, Guo Z, Liu Y, Li Y, et al. Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis. J Integr Plant Biol. 2016;58:959-970 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 6b
| Lubecka K, Kurzava L, Flower K, Buvala H, Zhang H, Teegarden D, et al. Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity. Carcinogenesis. 2016;37:656-68 pubmed publisher |
- western blot; human; fig 1
| Jayaram H, Hoelper D, Jain S, Cantone N, Lundgren S, Poy F, et al. S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3. Proc Natl Acad Sci U S A. 2016;113:6182-7 pubmed publisher |
- western blot; mouse; fig s6d
| Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352:844-9 pubmed publisher |
- ChIP-Seq; mouse
- western blot; mouse; fig 5
| Si S, Nakajima Takagi Y, Aoyama K, Oshima M, Saraya A, Sugishita H, et al. Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells. PLoS ONE. 2016;11:e0154561 pubmed publisher |
- chromatin immunoprecipitation; human; fig 4
| Kushwaha R, Jagadish N, Kustagi M, Mendiratta G, Seandel M, Soni R, et al. Mechanism and Role of SOX2 Repression in Seminoma: Relevance to Human Germline Specification. Stem Cell Reports. 2016;6:772-783 pubmed publisher |
- immunocytochemistry; human; 1:500; fig 6
| Douvaras P, Rusielewicz T, Kim K, Haines J, CASACCIA P, Fossati V. Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes. Int J Mol Sci. 2016;17: pubmed publisher |
- ChIP-Seq; mouse; fig 6
- western blot; mouse; fig s10
| Stelloh C, Reimer M, Pulakanti K, Blinka S, Peterson J, Pinello L, et al. The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing. Epigenetics Chromatin. 2016;9:14 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 4
| Cozzolino A, Noce V, Battistelli C, Marchetti A, Grassi G, Cicchini C, et al. Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes. Stem Cells Int. 2016;2016:5481493 pubmed publisher |
- chromatin immunoprecipitation; human; fig 6
| Wang Z, Xie J, Yan M, Wang J, Wang X, Zhang J, et al. Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma. Oncotarget. 2016;7:26765-79 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 4
- immunocytochemistry; mouse; 1:100; fig s8
| Faralli H, Wang C, Nakka K, Benyoucef A, Sebastian S, Zhuang L, et al. UTX demethylase activity is required for satellite cell-mediated muscle regeneration. J Clin Invest. 2016;126:1555-65 pubmed publisher |
- immunocytochemistry; human; 1:400
| Sagi I, Chia G, Golan Lev T, Peretz M, Weissbein U, Sui L, et al. Derivation and differentiation of haploid human embryonic stem cells. Nature. 2016;532:107-11 pubmed publisher |
- western blot; fruit fly ; 1:1000; fig 7
| Akan I, Love D, Harwood K, Bond M, Hanover J. Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O-GlcNAcylation. J Biol Chem. 2016;291:9906-19 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig s8
| Mo A, Luo C, Davis F, Mukamel E, Henry G, Nery J, et al. Epigenomic landscapes of retinal rods and cones. elife. 2016;5:e11613 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 2
| Benyoucef A, Palii C, Wang C, Porter C, Chu A, Dai F, et al. UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia. Genes Dev. 2016;30:508-21 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig s1
| Dhawan S, Dirice E, Kulkarni R, Bhushan A. Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. Diabetes. 2016;65:1208-18 pubmed publisher |
- chromatin immunoprecipitation; human; fig 1
| Castaño J, Morera C, Sesé B, Boue S, Bonet Costa C, Marti M, et al. SETD7 Regulates the Differentiation of Human Embryonic Stem Cells. PLoS ONE. 2016;11:e0149502 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 2
| Liu Y, Duong W, Krawczyk C, Bretschneider N, Borbély G, Varshney M, et al. Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase. Epigenetics Chromatin. 2016;9:7 pubmed publisher |
- chromatin immunoprecipitation; human; fig s3
| Brasa S, Mueller A, Jacquemont S, Hahne F, Rozenberg I, Peters T, et al. Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome. Clin Epigenetics. 2016;8:15 pubmed publisher |
- chromatin immunoprecipitation; human; fig 1
| Stein C, Nötzold R, Riedl S, Bouchard C, Bauer U. The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression. PLoS ONE. 2016;11:e0148892 pubmed publisher |
| Lin C, Erkek S, Tong Y, Yin L, Federation A, Zapatka M, et al. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature. 2016;530:57-62 pubmed publisher |
- western blot; human; loading ...; fig s3s
| Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, Iwasaki K, et al. Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. Proc Natl Acad Sci U S A. 2016;113:1273-8 pubmed publisher |
- chromatin immunoprecipitation; human; fig s7
| Vento Tormo R, Company C, RodrÃguez Ubreva J, de la Rica L, Urquiza J, Javierre B, et al. IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation. Genome Biol. 2016;17:4 pubmed publisher |
- immunohistochemistry; mouse; 1:500
| Murakami K, Günesdogan U, Zylicz J, Tang W, Sengupta R, Kobayashi T, et al. NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers. Nature. 2016;529:403-407 pubmed publisher |
- chromatin immunoprecipitation; human; fig 7
- western blot; human; 1:2000; fig 7
| MartÃnez Iglesias O, Alonso Merino E, Gómez Rey S, Velasco MartÃn J, MartÃn Orozco R, Luengo E, et al. Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis. Proc Natl Acad Sci U S A. 2016;113:E328-37 pubmed publisher |
- chromatin immunoprecipitation; mouse; loading ...; fig 7a
- western blot; mouse; loading ...; fig 7e
| Shields B, Jackson J, Metcalf D, Shi W, Huang Q, Garnham A, et al. Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a. Genes Dev. 2016;30:78-91 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 3
| Benitz S, Regel I, Reinhard T, Popp A, Schäffer I, Raulefs S, et al. Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells. Oncotarget. 2016;7:11424-33 pubmed publisher |
- ChIP-Seq; human; fig 2
- immunocytochemistry; human; fig s2
| Grandy R, Whitfield T, Wu H, Fitzgerald M, VanOudenhove J, Zaidi S, et al. Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation. Mol Cell Biol. 2016;36:615-27 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 2a
| Liu G, Zhao G, Chen X, Hao D, Zhao X, Lv X, et al. The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster. Nucleic Acids Res. 2016;44:2613-27 pubmed publisher |
- immunocytochemistry; pigs ; 1:200; fig 7B
| Kim E, Hwang S, Yoo H, Yoon J, Jeon Y, Kim H, et al. Putative embryonic stem cells derived from porcine cloned blastocysts using induced pluripotent stem cells as donors. Theriogenology. 2016;85:601-16 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Zhao E, Maj T, Kryczek I, Li W, Wu K, Zhao L, et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol. 2016;17:95-103 pubmed publisher |
| Tamming R, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, et al. Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Cell Rep. 2020;31:107838 pubmed publisher |
| Dunican D, Mjoseng H, Duthie L, Flyamer I, Bickmore W, Meehan R. Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells. BMC Biol. 2020;18:25 pubmed publisher |
| Chojnowski A, Ong P, Foo M, Liebl D, Hor L, Stewart C, et al. Heterochromatin loss as a determinant of progerin-induced DNA damage in Hutchinson-Gilford Progeria. Aging Cell. 2020;19:e13108 pubmed publisher |
| Ricci W, Lu Z, Ji L, Marand A, Ethridge C, Murphy N, et al. Widespread long-range cis-regulatory elements in the maize genome. Nat Plants. 2019;5:1237-1249 pubmed publisher |
| Huang Y, Mouttet B, Warnatz H, Risch T, Rietmann F, Frommelt F, et al. The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability. Cancer Cell. 2019;36:630-644.e9 pubmed publisher |
| Hanna C, Pérez Palacios R, Gahurova L, Schubert M, Krueger F, Biggins L, et al. Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues. Genome Biol. 2019;20:225 pubmed publisher |
| Qadeer Z, Valle García D, Hasson D, Sun Z, Cook A, Nguyen C, et al. ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures. Cancer Cell. 2019;36:512-527.e9 pubmed publisher |
| Anastas J, Zee B, Kalin J, Kim M, Guo R, Alexandrescu S, et al. Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019;36:528-544.e10 pubmed publisher |
| Inoue F, Kreimer A, Ashuach T, Ahituv N, Yosef N. Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction. Cell Stem Cell. 2019;25:713-727.e10 pubmed publisher |
| Ruta V, Longo C, Boccaccini A, Madia V, Saccoliti F, Tudino V, et al. Inhibition of Polycomb Repressive Complex 2 activity reduces trimethylation of H3K27 and affects development in Arabidopsis seedlings. BMC Plant Biol. 2019;19:429 pubmed publisher |
| Noce V, Battistelli C, Cozzolino A, Consalvi V, Cicchini C, Strippoli R, et al. YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation. Cell Death Dis. 2019;10:768 pubmed publisher |
| Rutowicz K, Lirski M, Mermaz B, Teano G, Schubert J, Mestiri I, et al. Linker histones are fine-scale chromatin architects modulating developmental decisions in Arabidopsis. Genome Biol. 2019;20:157 pubmed publisher |
| Petermann F, Pekowska A, Johnson C, Jankovic D, Shih H, Jiang K, et al. The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1. Mol Cell. 2019;75:1229-1242.e5 pubmed publisher |
| Wang C, Colognori D, Sunwoo H, Wang D, Lee J. PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments. Nat Commun. 2019;10:2950 pubmed publisher |
| Gushchanskaia E, Esse R, Ma Q, Lau N, Grishok A. Interplay between small RNA pathways shapes chromatin landscapes in C. elegans. Nucleic Acids Res. 2019;47:5603-5616 pubmed publisher |
| Zeng Z, Zhang W, Marand A, Zhu B, Buell C, Jiang J. Cold stress induces enhanced chromatin accessibility and bivalent histone modifications H3K4me3 and H3K27me3 of active genes in potato. Genome Biol. 2019;20:123 pubmed publisher |
| Hu X, Liu Z, Chen X, Schulz V, Kumar A, Hartman A, et al. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nat Commun. 2019;10:1695 pubmed publisher |
| Zhu W, Xu X, Wang X, Liu J. Reprogramming histone modification patterns to coordinate gene expression in early zebrafish embryos. BMC Genomics. 2019;20:248 pubmed publisher |
| Fukushima H, Takeda H, Nakamura R. Targeted in vivo epigenome editing of H3K27me3. Epigenetics Chromatin. 2019;12:17 pubmed publisher |
| Liu X, Wang Y, Lu H, Li J, Yan X, Xiao M, et al. Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction. Nature. 2019;567:525-529 pubmed publisher |
| Shivram H, Le S, Iyer V. MicroRNAs reinforce repression of PRC2 transcriptional targets independently and through a feed-forward regulatory network. Genome Res. 2019;29:184-192 pubmed publisher |
| Wang H, Long Q, Tang S, Xiao Q, Gao C, Zhao Q, et al. Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer. Nucleic Acids Res. 2019;47:2349-2364 pubmed publisher |
| Yang L, Zha Y, Ding J, Ye B, Liu M, Yan C, et al. Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation. Oncogenesis. 2019;8:3 pubmed publisher |
| Al Raawi D, Jones R, Wijesinghe S, Halsall J, Petric M, Roberts S, et al. A novel form of JARID2 is required for differentiation in lineage-committed cells. EMBO J. 2019;38: pubmed publisher |
| Dworak N, Mąkosa D, Chatterjee M, Jividen K, Yang C, Snow C, et al. A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling. Aging Cell. 2019;18:e12851 pubmed publisher |
| Hajduskova M, Baytek G, Kolundžić E, Gosdschan A, Kazmierczak M, Ofenbauer A, et al. MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegans. Genetics. 2019;211:121-139 pubmed publisher |
| Li Y, He Q, Wen X, Hong X, Yang X, Tang X, et al. EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma. Cell Death Differ. 2019;26:1089-1106 pubmed publisher |
| Jang Y, Broun A, Wang C, Park Y, Zhuang L, Lee J, et al. H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development. Nucleic Acids Res. 2019;47:607-620 pubmed publisher |
| Erkek S, Johann P, Finetti M, Drosos Y, Chou H, Zapatka M, et al. Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation. Cancer Cell. 2018;: pubmed publisher |
| Zhang Q, Tran T, Wang M, Ranek M, Kokkonen Simon K, Gao J, et al. Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis. Nat Commun. 2018;9:5230 pubmed publisher |
| Aries I, Bodaar K, Karim S, Chonghaile T, Hinze L, Burns M, et al. PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. J Exp Med. 2018;215:3094-3114 pubmed publisher |
| Pattison J, Melo S, Piekos S, Torkelson J, Bashkirova E, Mumbach M, et al. Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. Nat Genet. 2018;50:1658-1665 pubmed publisher |
| Moon S, Im S, Kim N, Youn H, Park U, Kim J, et al. Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. Cell Death Dis. 2018;9:1118 pubmed publisher |
| Adhikary G, Grun D, Alexander H, Friedberg J, Xu W, Keillor J, et al. Transglutaminase is a mesothelioma cancer stem cell survival protein that is required for tumor formation. Oncotarget. 2018;9:34495-34505 pubmed publisher |
| Svedberg J, Hosseini S, Chen J, Vogan A, Mozgová I, Hennig L, et al. Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements. Nat Commun. 2018;9:4242 pubmed publisher |
| van de Lagemaat L, Flenley M, Lynch M, Garrick D, Tomlinson S, Kranc K, et al. CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands. Epigenetics Chromatin. 2018;11:59 pubmed publisher |
| Ogawa C, Bankoti R, Nguyen T, Hassanzadeh Kiabi N, Nadeau S, Porritt R, et al. Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells. Cell Rep. 2018;25:19-28.e5 pubmed publisher |
| Damodaran K, Venkatachalapathy S, Alisafaei F, Radhakrishnan A, Sharma Jokhun D, Shenoy V, et al. Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response. Mol Biol Cell. 2018;:mbcE18040256 pubmed publisher |
| Wang Y, Long H, Yu J, Dong L, Wassef M, Zhuo B, et al. Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells. BMC Biol. 2018;16:107 pubmed publisher |
| Stringer J, Forster S, Qu Z, Prokopuk L, O Bryan M, Gardner D, et al. Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance. BMC Biol. 2018;16:104 pubmed publisher |
| Vandenbon A, Kumagai Y, Lin M, Suzuki Y, Nakai K. Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation. Genome Biol. 2018;19:138 pubmed publisher |
| Zhang P, He F, Bai J, Yamamoto S, Chen S, Zhang L, et al. Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy. J Clin Invest. 2018;128:5383-5398 pubmed publisher |
| Bhullar S, Denby Wilkes C, Arnaiz O, Nowacki M, Sperling L, Meyer E. A mating-type mutagenesis screen identifies a zinc-finger protein required for specific DNA excision events in Paramecium. Nucleic Acids Res. 2018;46:9550-9562 pubmed publisher |
| Hu P, Nebreda A, Hanenberg H, Kinnebrew G, Ivan M, Yoder M, et al. P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim. Nat Commun. 2018;9:3518 pubmed publisher |
| Gillman A, Parker G, Allday M, Bazot Q. Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of COBLL1 and the ADAM28-ADAMDEC1 Locus via Interaction with the Histone Lysine Demethylase KDM2B. J Virol. 2018;92: pubmed publisher |
| Yu Z, Jiang K, Xu Z, Huang H, Qian N, Lu Z, et al. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration. Cell Stem Cell. 2018;23:487-500.e6 pubmed publisher |
| Gits H, Anderson M, Stallard S, Pratt D, Zon B, Howell C, et al. Medulloblastoma therapy generates risk of a poorly-prognostic H3 wild-type subgroup of diffuse intrinsic pontine glioma: a report from the International DIPG Registry. Acta Neuropathol Commun. 2018;6:67 pubmed publisher |
| Matoba S, Wang H, Jiang L, Lu F, Iwabuchi K, Wu X, et al. Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development. Cell Stem Cell. 2018;23:343-354.e5 pubmed publisher |
| Soleimani V, Nguyen D, Ramachandran P, Palidwor G, Porter C, Yin H, et al. Cis-regulatory determinants of MyoD function. Nucleic Acids Res. 2018;46:7221-7235 pubmed publisher |
| Liu C, Wang R, He Z, Osteil P, Wilkie E, Yang X, et al. Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells. Stem Cell Reports. 2018;11:43-57 pubmed publisher |
| Gu T, Lin X, Cullen S, Luo M, Jeong M, Estecio M, et al. DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells. Genome Biol. 2018;19:88 pubmed publisher |
| Tanaka S, Jiang Y, Martinez G, Tanaka K, Yan X, Kurosaki T, et al. Trim33 mediates the proinflammatory function of Th17 cells. J Exp Med. 2018;215:1853-1868 pubmed publisher |
| Kaneko S, Li X. X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism. Sci Adv. 2018;4:eaar5598 pubmed publisher |
| Wang C, Jégu T, Chu H, Oh H, Lee J. SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X. Cell. 2018;174:406-421.e25 pubmed publisher |
| Hsu A, Lupancu T, Lee M, Fleetwood A, Cook A, Hamilton J, et al. Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages. J Biol Chem. 2018;293:11415-11423 pubmed publisher |
| Denisenko O, Mar D, Trawczynski M, Bomsztyk K. Chromatin changes trigger laminin genes dysregulation in aging kidneys. Aging (Albany NY). 2018;10:1133-1145 pubmed publisher |
| Wang H, Jiang D, Axelsson E, Lorkovic Z, Montgomery S, Holec S, et al. LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2. Mol Plant. 2018;11:1038-1052 pubmed publisher |
| Zhuang L, Jang Y, Park Y, Lee J, Jain S, Froimchuk E, et al. Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018;9:1796 pubmed publisher |
| Pradhan R, Ranade D, Sengupta K. Emerin modulates spatial organization of chromosome territories in cells on softer matrices. Nucleic Acids Res. 2018;46:5561-5586 pubmed publisher |
| Nagase R, Inoue D, Pastore A, Fujino T, Hou H, Yamasaki N, et al. Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation. J Exp Med. 2018;215:1729-1747 pubmed publisher |
| Chen G, Subedi K, Chakraborty S, Sharov A, Lu J, Kim J, et al. Ezh2 Regulates Activation-Induced CD8+ T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression. Front Immunol. 2018;9:549 pubmed publisher |
| Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, et al. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018;70:408-421.e8 pubmed publisher |
| Dong Z, Yu J, Li H, Huang W, Xu L, Zhao Y, et al. Transcriptional and epigenetic adaptation of maize chromosomes in Oat-Maize addition lines. Nucleic Acids Res. 2018;46:5012-5028 pubmed publisher |
| Hall A, Battenhouse A, Shivram H, Morris A, Cowperthwaite M, Shpak M, et al. Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells. Cancer Res. 2018;78:2463-2474 pubmed publisher |
| Caruso L, Martin K, Lauretti E, Hulse M, Siciliano M, Lupey Green L, et al. Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage. Oncotarget. 2018;9:10585-10605 pubmed publisher |
| Dobenecker M, Park J, Marcello J, McCabe M, Gregory R, Knight S, et al. Signaling function of PRC2 is essential for TCR-driven T cell responses. J Exp Med. 2018;215:1101-1113 pubmed publisher |
| Li Z, Takenobu H, Setyawati A, Akita N, Haruta M, Satoh S, et al. EZH2 regulates neuroblastoma cell differentiation via NTRK1 promoter epigenetic modifications. Oncogene. 2018;37:2714-2727 pubmed publisher |
| Banito A, Li X, Laporte A, Roe J, Sanchez Vega F, Huang C, et al. The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Cancer Cell. 2018;33:527-541.e8 pubmed publisher |
| Xi Y, Shi J, Li W, Tanaka K, Allton K, Richardson D, et al. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics. 2018;19:150 pubmed publisher |
| Fueyo R, Iacobucci S, PAPPA S, Estarás C, Lois S, Vicioso Mantis M, et al. Lineage specific transcription factors and epigenetic regulators mediate TGF?-dependent enhancer activation. Nucleic Acids Res. 2018;46:3351-3365 pubmed publisher |
| Sun B, Chang E, Gerhartl A, Szele F. Polycomb Protein Eed is Required for Neurogenesis and Cortical Injury Activation in the Subventricular Zone. Cereb Cortex. 2018;28:1369-1382 pubmed publisher |
| Gu W, Mochizuki K, Otsuka K, Hamada R, Takehara A, Matsui Y. Dnd1-mediated epigenetic control of teratoma formation in mouse. Biol Open. 2018;7: pubmed publisher |
| Bazot Q, Paschos K, Allday M. Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV. J Virol. 2018;92: pubmed publisher |
| Xu M, Leichty A, Hu T, Poethig R. H2A.Z promotes the transcription of MIR156A and MIR156C in Arabidopsis by facilitating the deposition of H3K4me3. Development. 2018;145: pubmed publisher |
| Vo L, Kinney M, Liu X, Zhang Y, Barragan J, Sousa P, et al. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018;553:506-510 pubmed publisher |
| Gell J, Zhao J, Chen D, Hunt T, Clark A. PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation. Stem Cell Res. 2018;27:46-56 pubmed publisher |
| Guo M, Price M, Patterson D, Barwick B, Haines R, Kania A, et al. EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. J Immunol. 2018;200:1039-1052 pubmed publisher |
| Leadem B, Kagiampakis I, Wilson C, Cheung T, Arnott D, Trojer P, et al. A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine. Cancer Res. 2018;78:1127-1139 pubmed publisher |
| Chen L, Alexe G, Dharia N, Ross L, Iniguez A, Conway A, et al. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. J Clin Invest. 2018;128:446-462 pubmed publisher |
| Bogeas A, Morvan Dubois G, El Habr E, Lejeune F, Defrance M, Narayanan A, et al. Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness. Acta Neuropathol. 2018;135:267-283 pubmed publisher |
| Song S, Jeon M, Nam J, Kang J, Lee Y, Kang J, et al. Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer. Oncogene. 2018;37:993-1004 pubmed publisher |
| Kaushik S, Liu F, Veazey K, Gao G, Das P, Neves L, et al. Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML. Leukemia. 2018;32:499-509 pubmed publisher |
| Lui J, Barnes K, Dong L, Yue S, Graber E, Rapaport R, et al. Ezh2 mutations found in the Weaver overgrowth syndrome cause a partial loss of H3K27 histone methyltransferase activity. J Clin Endocrinol Metab. 2017;: pubmed publisher |
| Niskanen H, Tuszynska I, Zaborowski R, Heinaniemi M, Yla Herttuala S, Wilczynski B, et al. Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions. Nucleic Acids Res. 2017;: pubmed publisher |
| Berry S, Rosa S, Howard M, Buhler M, Dean C. Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression. Genes Dev. 2017;31:2115-2120 pubmed publisher |
| Sánchez Cid L, Pons M, Lozano J, Rubio N, Guerra Rebollo M, Soriano A, et al. MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells. Oncotarget. 2017;8:83384-83406 pubmed publisher |
| Kiese K, Jablonski J, Hackenbracht J, Wrosch J, Groemer T, Kornhuber J, et al. Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons. Acta Neuropathol Commun. 2017;5:79 pubmed publisher |
| Stroud H, Su S, Hrvatin S, Greben A, Renthal W, Boxer L, et al. Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States. Cell. 2017;171:1151-1164.e16 pubmed publisher |
| Poleshko A, Shah P, Gupta M, Babu A, Morley M, Manderfield L, et al. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell. 2017;171:573-587.e14 pubmed publisher |
| Pan X, Fang Y, Yang X, Zheng D, Chen L, Wang L, et al. Chromatin states responsible for the regulation of differentially expressed genes under 60Co~γ ray radiation in rice. BMC Genomics. 2017;18:778 pubmed publisher |
| Izquierdo Bouldstridge A, Bustillos A, Bonet Costa C, Aribau Miralbés P, García Gomis D, Dabad M, et al. Histone H1 depletion triggers an interferon response in cancer cells via activation of heterochromatic repeats. Nucleic Acids Res. 2017;45:11622-11642 pubmed publisher |
| Omori Y, Kubo S, Kon T, Furuhashi M, Narita H, Kominami T, et al. Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity. Proc Natl Acad Sci U S A. 2017;114:E8264-E8273 pubmed publisher |
| Yao X, Tan J, Lim K, Koh J, Ooi W, Li Z, et al. VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2017;7:1284-1305 pubmed publisher |
| Li H, Liefke R, Jiang J, Kurland J, Tian W, Deng P, et al. Polycomb-like proteins link the PRC2 complex to CpG islands. Nature. 2017;549:287-291 pubmed publisher |
| David S, Piegu B, Hennequet Antier C, Pannetier M, Aguirre Lavin T, Crochet S, et al. An Assessment of Fixed and Native Chromatin Preparation Methods to Study Histone Post-Translational Modifications at a Whole Genome Scale in Skeletal Muscle Tissue. Biol Proced Online. 2017;19:10 pubmed publisher |
| Lyu Y, Nakano K, Davis R, Tepper C, Campbell M, Izumiya Y. ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation. J Virol. 2017;91: pubmed publisher |
| Zhu W, Hu B, Becker C, Doğan E, Berendzen K, Weigel D, et al. Altered chromatin compaction and histone methylation drive non-additive gene expression in an interspecific Arabidopsis hybrid. Genome Biol. 2017;18:157 pubmed publisher |
| Schwarzer A, Emmrich S, Schmidt F, Beck D, Ng M, Reimer C, et al. The non-coding RNA landscape of human hematopoiesis and leukemia. Nat Commun. 2017;8:218 pubmed publisher |
| Shih C, Chang Y, Huang W, Jang T, Kung H, Wang W, et al. EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis. Oncogene. 2017;36:6542-6554 pubmed publisher |
| Wang S, Tang Z, Chen C, Shimada M, Koche R, Wang L, et al. A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription. Mol Cell. 2017;67:308-321.e6 pubmed publisher |
| Liu P, Wang H, Li X, Chao T, Teav T, Christen S, et al. ?-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat Immunol. 2017;18:985-994 pubmed publisher |
| Yang R, Zheng Z, Chen Q, Yang L, Huang H, Miki D, et al. The developmental regulator PKL is required to maintain correct DNA methylation patterns at RNA-directed DNA methylation loci. Genome Biol. 2017;18:103 pubmed publisher |
| Semba Y, Harada A, Maehara K, Oki S, Meno C, Ueda J, et al. Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells. Nucleic Acids Res. 2017;45:8758-8772 pubmed publisher |
| Aldiri I, Xu B, Wang L, Chen X, Hiler D, Griffiths L, et al. The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis. Neuron. 2017;94:550-568.e10 pubmed publisher |
| Eun S, Feng L, Cedeno Rosario L, Gan Q, Wei G, Cui K, et al. Polycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis. J Mol Biol. 2017;429:2030-2041 pubmed publisher |
| Lai B, Lee J, Jang Y, Wang L, Peng W, Ge K. MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis. Nucleic Acids Res. 2017;45:6388-6403 pubmed publisher |
| Kanki Y, Nakaki R, Shimamura T, Matsunaga T, Yamamizu K, Katayama S, et al. Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation. Nucleic Acids Res. 2017;45:4344-4358 pubmed publisher |
| Choi J, Yoon S, Kim S, Ahn Jo S. KDM4B histone demethylase and G9a regulate expression of vascular adhesion proteins in cerebral microvessels. Sci Rep. 2017;7:45005 pubmed publisher |
| Song A, Jiang S, Wang Q, Zou J, Lin Z, Gao X. JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin-Estrogen Feedback Loop and Reproductive Function. Endocrinology. 2017;158:1798-1811 pubmed publisher |
| Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017;36:1243-1260 pubmed publisher |
| Coleman R, Struhl G. Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene. Science. 2017;356: pubmed publisher |
| Sato Y, Katoh Y, Matsumoto M, Sato M, Ebina M, Itoh Nakadai A, et al. Regulatory signatures of liver regeneration distilled by integrative analysis of mRNA, histone methylation, and proteomics. J Biol Chem. 2017;292:8019-8037 pubmed publisher |
| Hatch S, Yapp C, Montenegro R, Savitsky P, Gamble V, Tumber A, et al. Assessing histone demethylase inhibitors in cells: lessons learned. Epigenetics Chromatin. 2017;10:9 pubmed publisher |
| Liu K, Mao J, Song L, Fan A, Zhang S, Wang J, et al. DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells. PLoS ONE. 2017;12:e0173047 pubmed publisher |
| van Arensbergen J, Dussaud S, Pardanaud Glavieux C, García Hurtado J, Sauty C, Guerci A, et al. A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element. PLoS ONE. 2017;12:e0171508 pubmed publisher |
| Zhu A, Greaves I, Dennis E, Peacock W. Genome-wide analyses of four major histone modifications in Arabidopsis hybrids at the germinating seed stage. BMC Genomics. 2017;18:137 pubmed publisher |
| Kundu S, Ji F, Sunwoo H, Jain G, Lee J, Sadreyev R, et al. Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Mol Cell. 2017;65:432-446.e5 pubmed publisher |
| Park J, Kwon Y, Ham S, Hong C, Seo S, Choe M, et al. Identification of the early and late responder genes during the generation of induced pluripotent stem cells from mouse fibroblasts. PLoS ONE. 2017;12:e0171300 pubmed publisher |
| Sun R, Tan X, Wang X, Wang X, Yang L, Robertson E, et al. Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues. PLoS Pathog. 2017;13:e1006167 pubmed publisher |
| Lyroni K, Patsalos A, Daskalaki M, Doxaki C, Soennichsen B, Helms M, et al. Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages. J Immunol. 2017;198:1297-1307 pubmed publisher |
| Liau B, Sievers C, Donohue L, Gillespie S, Flavahan W, Miller T, et al. Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Cell Stem Cell. 2017;20:233-246.e7 pubmed publisher |
| Angela M, Endo Y, Asou H, Yamamoto T, Tumes D, Tokuyama H, et al. Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPAR? directs early activation of T cells. Nat Commun. 2016;7:13683 pubmed publisher |
| Cubeñas Potts C, Rowley M, Lyu X, Li G, Lei E, Corces V. Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture. Nucleic Acids Res. 2017;45:1714-1730 pubmed publisher |
| Xia B, Gerstin E, Schones D, Huang W, Steven de Belle J. Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila. Aging (Albany NY). 2016;8:2988-3008 pubmed publisher |
| Weischenfeldt J, Dubash T, Drainas A, Mardin B, Chen Y, Stütz A, et al. Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Nat Genet. 2017;49:65-74 pubmed publisher |
| Noguera N, Piredda M, Taulli R, Catalano G, Angelini G, Gaur G, et al. PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity. Oncotarget. 2016;7:66386-66397 pubmed publisher |
| Oza J, Ganguly B, Kulkarni A, Ginjala V, Yao M, Ganesan S. A Novel Role of Chromodomain Protein CBX8 in DNA Damage Response. J Biol Chem. 2016;291:22881-22893 pubmed |
| von Schimmelmann M, Feinberg P, Sullivan J, Ku S, Badimon A, Duff M, et al. Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration. Nat Neurosci. 2016;19:1321-30 pubmed publisher |
| Battistelli C, Cicchini C, Santangelo L, Tramontano A, Grassi L, Gonzalez F, et al. The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition. Oncogene. 2017;36:942-955 pubmed publisher |
| Teng F, Guo M, Liu F, Wang C, Dong J, Zhang L, et al. Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas. Oncotarget. 2016;7:53571-53582 pubmed publisher |
| Riso V, Cammisa M, Kukreja H, Anvar Z, Verde G, Sparago A, et al. ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells. Nucleic Acids Res. 2016;44:8165-78 pubmed publisher |
| Meredith E, Balas M, Sindy K, Haislop K, JOHNSON A. An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR. RNA. 2016;22:995-1010 pubmed publisher |
| Wang J, Singh M, Sun C, Besser D, Prigione A, Ivics Z, et al. Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression. Nat Protoc. 2016;11:327-46 pubmed publisher |
| Mursalimov S, Permyakova N, Deineko E, Houben A, Demidov D. Cytomixis doesn't induce obvious changes in chromatin modifications and programmed cell death in tobacco male meiocytes. Front Plant Sci. 2015;6:846 pubmed publisher |
| Ohhata T, Matsumoto M, Leeb M, Shibata S, Sakai S, Kitagawa K, et al. Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression. Mol Cell Biol. 2015;35:3909-20 pubmed publisher |
| Kawamura K, Kinoshita M, Sekida S, Sunanaga T. Histone methylation codes involved in stemness, multipotency, and senescence in budding tunicates. Mech Ageing Dev. 2015;145:1-12 pubmed publisher |
| Patel S, Bhumbra S, Paknikar R, Dressler G. Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression. Mol Cell. 2012;45:185-95 pubmed publisher |
| Mandal M, Powers S, Maienschein Cline M, Bartom E, Hamel K, Kee B, et al. Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2. Nat Immunol. 2011;12:1212-20 pubmed publisher |
| Selinger C, Cooper W, Al Sohaily S, Mladenova D, Pangon L, Kennedy C, et al. Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. J Thorac Oncol. 2011;6:1179-89 pubmed publisher |
| Liu Y, Taverna S, Muratore T, Shabanowitz J, Hunt D, Allis C. RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev. 2007;21:1530-45 pubmed |
