AMPK α1 Antibody | EMD Millipore 07-350 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

AMPK α1 Antibody

catalog :

07-350

quantity :

200 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 3e	Liu T, Han S, Dai Q, Zheng J, Liu C, Li S, et al. IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway. Front Immunol. 2019;10:2952 pubmed publisher
western blot; mouse; loading ...; fig 1a, 1g, 2b, 2d, 5a	Bultot L, Jensen T, Lai Y, Madsen A, Collodet C, Kviklyte S, et al. Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle. Am J Physiol Endocrinol Metab. 2016;311:E706-E719 pubmed publisher
	Roa J, Barroso A, Ruiz Pino F, Vazquez M, Seoane Collazo P, Martínez Sánchez N, et al. Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling. Proc Natl Acad Sci U S A. 2018;115:E10758-E10767 pubmed publisher

product information

Catalog Number :

07-350

Subcategory :

Cell Signaling

Product Name :

Anti-AMPK α1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q13131

Host Name :

Rabbit

Antigen :

AMPK α1

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-AMPK α1 Antibody

Cross Reactivity :

Human;Rat;Mouse

Background :

AMP-activated protein kinase (AMPK) is a metabolic and stress-sensing kinase that regulates homeostasis, and a key target for treating Type 2 diabetes and obesity. AMPK exists as a heterotrimeric complex comprised of catalytic alpha subunits (62 kDa) and non-catalytic beta and gamma subunits. The Alpha subunit has at least two isoforms (alpha 1 and alpha 2) that differ in their subcellular localization and AMP-dependence. AMPK is phosphorylated by upstream kinases, AMPK Kinase (AMPKK) and LKB1 which results in its activation. Active AMPK regulates metabolism by phosphorylating rate-limiting enzymes in metabolic pathways and controlling gene expression. Phosphorylation of threonine 172 in the activation loop of the alpha subunit is a key determinant of AMPK activity.

ALT Names :

5'-AMP-activated protein kinase, catalytic alpha-1 chain;AMP -activate kinase alpha 1 subunit;AMP-activated protein kinase, catalytic, alpha-1;AMPK alpha 1;AMPK alpha-1 chain;protein kinase, AMP-activated, alpha 1 catalytic subunit

Immunogen :

KLH-conjugated synthetic peptide corresponding to amino acids 376-392 (C-ARHTLDELNPQKSKHQG-COOH) of human AMP-activated Protein Kinase α1.

Specificity :

AMPKα1

Package Size :

200 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt