acetyl-Histone H4 (Lys8) Antibody | EMD Millipore 07-328 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

acetyl-Histone H4 (Lys8) Antibody

catalog :

07-328

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 3

Reference
Xi Y, Shi J, Li W, Tanaka K, Allton K, Richardson D, et al. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics. 2018;19:150 pubmed publisher
Korb E, Herre M, Zucker Scharff I, Gresack J, Allis C, Darnell R. Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Cell. 2017;170:1209-1223.e20 pubmed publisher
Wu D, Zhao L, Feng Z, Yu C, Ding J, Wang L, et al. O-Linked N-acetylglucosamine transferase 1 regulates global histone H4 acetylation via stabilization of the nonspecific lethal protein NSL3. J Biol Chem. 2017;292:10014-10025 pubmed publisher

product information

Catalog Number :

07-328

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-acetyl-Histone H4 (Lys8) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P62805

Host Name :

Rabbit

Antigen :

acetyl-Histone H4 (Lys8)

Conjugate :

Serum

Isotype :

IgG

Product Description :

Anti-acetyl-Histone H4 (Lys8) Antibody

Cross Reactivity :

Human;Yeast ( S. cerevisiae )

Background :

Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H4 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

ALT Names :

H4K8Ac;Histone H4 (acetyl K8)

Immunogen :

Peptide corresponding to amino acids 3-13 of yeast Histone H4 (RGKGG Ac KGLGKG-C) in which lysine 8 is acetylated.

Specificity :

Recognizes acetyl-Histone H4 (Lys8).

Package Size :

100 μL

Uses :

Immunoprecipitation;Western Blotting;Dot Blot;ChIP-seq

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.