phospho-STAT1 (Tyr701) Antibody | EMD Millipore 07-307 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-STAT1 (Tyr701) Antibody

catalog :

07-307

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, chicken

application :

western blot

product information

Catalog Number :

07-307

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-STAT1 (Tyr701) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P42224

Host Name :

Rabbit

Antigen :

phospho-STAT1 (Tyr701)

Conjugate :

Affinity Purified

Isotype :

IgG

Product Description :

Anti-phospho-STAT1 (Tyr701) Antibody

Cross Reactivity :

Mouse;Human;Chicken;Rat

Background :

STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. STAT 1, is activated by a number of different ligands, including IFNalpha, IFNgamma, EGF, PDGF and IL6. Phosphorylation of tyrosine 701 is required for STAT 1 dissociation from IFNGR1, homodimerization, and nuclear translocation. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions.

ALT Names :

Transcription factor ISGF-3 components p91/p84;signal transducer and activator of transcription 1;signal transducer and activator of transcription 1, 91kD;signal transducer and activator of transcription 1, 91kDa;signal transducer and activator of transcription-1

Immunogen :

KLH-conjugated synthetic peptide (C-DDPKRTG[pY]IKTE) corresponding to amino acids 694-705 of mouse STAT1, containing a N-terminal cysteine.

Specificity :

Phosphorylated STAT1

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.