AUF1 Antibody | EMD Millipore 07-260 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

AUF1 Antibody

catalog :

07-260

quantity :

200 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; loading ...; fig 5	Evans H, Bodea L, Götz J. Cell-specific non-canonical amino acid labelling identifies changes in the de novo proteome during memory formation. elife. 2020;9: pubmed publisher
western blot; mouse; loading ...; fig 3c	Nyati K, Masuda K, Zaman M, Dubey P, Millrine D, Chalise J, et al. TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a. Nucleic Acids Res. 2017;45:2687-2703 pubmed publisher
	Fragkouli A, Koukouraki P, Vlachos I, Paraskevopoulou M, Hatzigeorgiou A, Doxakis E. Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP. Sci Rep. 2017;7:44507 pubmed publisher
	Li S, Zhang H, Du Z, Li C, An M, Zong Z, et al. Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells. Oncotarget. 2016;7:70364-70377 pubmed publisher

product information

Catalog Number :

07-260

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-AUF1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q14103

Host Name :

Rabbit

Antigen :

AUF1

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-AUF1 Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

A+U Rich RNA Binding Factor (AUF1) is comprised of four isoforms of 37, 40, 42, and 45 kDa. Although the role of each isoform has yet to be fully characterized, a direct correlation has been observed between each AUF1 isoform’s binding affinity and its RNA destabilizing activity toward different AREs (A + U rich element in the 3’ untranslated region), with the isoforms p37 and p42 being the most effective. AUF1 is a bcl2 mRNA binding protein and potentially all its isoforms are able to form complexes with the bcl2 ARE. ARE mediated bcl2 mRNA downregulation during apoptosis involves AUF1 and suggest different roles for its four isoforms.

Immunogen :

Purified AUF1

Specificity :

Recognizes AUF1 isoforms.

Package Size :

200 μg

Uses :

Western Blotting

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.