mSIN1 Antibody | EMD Millipore 07-2276 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

mSIN1 Antibody

catalog :

07-2276

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 3	Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher
	Holmes B, Benavides Serrato A, Freeman R, Landon K, Bashir T, Nishimura R, et al. mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma. Oncogene. 2017;: pubmed publisher
	Zheng B, Mao J, Li X, Qian L, Zhu H, Gu D, et al. Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2? expression and cell proliferation. Sci Rep. 2016;6:29415 pubmed publisher

product information

Catalog Number :

07-2276

Subcategory :

Cell Signaling

Product Name :

Anti-mSIN1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q9BPZ7

Host Name :

Rabbit

Antigen :

mSIN1

Conjugate :

Affinity Purified

Product Description :

Anti-mSIN1 Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

mSIN1 (mamalian stress-activated protein kinase (SAPK)-interacting protein 1, MAPKAP1) is an essential component of the Torc2 complex. mTORC2 is comprised of mTOR, a large Ser/Thr protein kinase along with SIN1, GbL (mLST8), Protor1, Protor2, and Rictor. The complex that is activated primarily downstream of PI3 Kinase is known to affect cell proliferation and survival primarily by phosphorylating Akt on Ser473. Additionally, the mTORC2 complex is also known to effect cytoskeletal organization and migration by exerting its effects through Rac, Rho, and PKC. SIN1 is also known to directly interact without proteins that include Ras, SPAKs, and JNK.

ALT Names :

MEKK2-interacting protein 1;Mitogen-activated protein kinase 2-associated protein 1;SAPK-interacting protein 1;Stress-activated map kinase-interacting protein 1;TORC2 subunit MAPKAP1;mitogen-activated protein kinase associated protein 1;ras inhibitor MGC2745;stress-activated map kinase interacting protein 1;stress-activated protein kinase-interacting 1

Immunogen :

KLH-conjugated linear peptide corresponding to human mSIN1.

Specificity :

This antibody recognizes mSIN1.

Package Size :

100 µL

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt