phospho-TBC1D1 Antibody (Ser237) | EMD Millipore 07-2268 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-TBC1D1 Antibody (Ser237)

catalog :

07-2268

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat, chimpanzee

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; rat; fig 2	Kawamoto E, Koshinaka K, Yoshimura T, Masuda H, Kawanaka K. Immobilization rapidly induces muscle insulin resistance together with the activation of MAPKs (JNK and p38) and impairment of AS160 phosphorylation. Physiol Rep. 2016;4: pubmed publisher
western blot; mouse; fig 4	Møller C, Kjøbsted R, Enriori P, Jensen T, Garcia Rudaz C, Litwak S, et al. ?-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK. PLoS ONE. 2016;11:e0157027 pubmed publisher
	Henríquez Olguín C, Knudsen J, Raun S, Li Z, Dalbram E, Treebak J, et al. Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise. Nat Commun. 2019;10:4623 pubmed publisher

product information

Catalog Number :

07-2268

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-TBC1D1 Antibody (Ser237)

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q86TI0

Host Name :

Rabbit

Antigen :

phospho-TBC1D1 (Ser237)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-TBC1D1 Antibody (Ser237)

Cross Reactivity :

Human;Mouse;Rat;Chimpanzee;Rhesus Macaque;Ox

Background :

TBC1D1 is the first member of a family of proteins that contain the tbc box motif of 180-220 amino acids and may be related to cell growth and differentiation. The composition of TBC1D1 has the same function as a known regulator of insulin-mediated Glut4 translocation and may play a role in severe human obesity. An insulin-independent increase in glucose transport several hours after exercise has been attributed to TBC1D1 phosphorylation. The R125W mutation of TBC1D1 is thought to decrease skeletal muscle glucose transport and could be the main reason for the obesity that seems to be linked to this type of mutation.

ALT Names :

TBC1 domain family member 1;TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1

Immunogen :

KLH-conjugated linear peptide corresponding to human TBC1D1 phosphorylated at Ser237.

Specificity :

This antibody recognizes TBC1D1 phosphorylated at Ser237.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt